[摘要]目的：探究抗生素骨水泥联合VSD在皮瓣修复压疮感染性创面中的应用效果。方法：选取2020年1月-2023年1月笔者医院收治的96例感染性压疮创面患者，依据治疗方式不同分为对照组(n=46)和观察组(n=50)。两组均行皮瓣修复术封闭创面，皮瓣修复术前，除常规清创消毒外，对照组采用单纯VSD治疗，观察组采用抗生素骨水泥联合VSD治疗。统计比较两组清创次数、创面愈合时间、术后住院时间，对比两组治疗前后的血清炎症因子水平变化，评价两组治疗后的疼痛程度及美观满意度。结果：观察组的清创次数少于对照组，创面愈合时间及住院时间短于对照组，差异均有统计学意义(P<0.05)。治疗2周后，观察组的白介素-6(IL-6)、前列腺素E2(PGE2)、C反应蛋白(CRP)、γ-干扰素(INF-γ)水平均低于对照组(P<0.05)。治疗1个月后，观察组疼痛程度明显比对照组轻(P<0.05)。术后3个月，观察组的美观满意度明显更高(P<0.05)。结论：抗生素骨水泥联合VSD技术用于皮瓣修复压疮感染性创面中，可促进创面愈合，改善炎症因子水平，减轻疼痛，提升患者的舒适度。

    [关键词]压疮；感染性创面；负压封闭引流(VSD)；抗生素骨水泥；炎症因子

    [中图分类号]R622" " [文献标志码]A" " [文章编号]1008-6455(2025)09-0044-04

    Application of Antibiotic-loaded Bone Cement Combined with VSD in Flap Reconstruction for Infected Pressure Ulcer Wounds

    LUO Xiaojiang， YANG Deqiong

    ( Department of Plastic and Reconstructive Surgery， Affiliated Three Gorges Hospital of Chongqing University， Chongqing 404100， China )

    Abstract： Objective" To explore the application effect of antibiotic-loaded bone cement combined with VSD in flap repair of infectious pressure ulcer wounds. Methods" A total of 96 patients with infectious pressure ulcer wounds to the author's hospital from January 2020 to January 2023 were selected and divided into the control group (n=46) and the observation group (n=50) according to different treatment methods. Both groups underwent flap repair to close the wound surface. Before flap repair ......