[摘要]目的：探究碱性成纤维细胞生长因子(Basic fibroblast growth factor，bFGF)联合中性氧化电位水敷料促进Ⅱ度烧伤创面修复的效果。方法：选取2022年1月-2024年2月笔者医院收治的100例Ⅱ度烧伤患者为研究对象，按随机数字表法分为观察组和对照组，各50例。对照组给予中性氧化电位水创面液体敷料治疗局部创面；观察组给予bFGF喷涂于创面及周围，创面予以中性氧化电位水创面液体敷料覆盖。比较两组创面愈合情况、换药情况、创面细菌培养情况及治疗前后血清促红细胞生成素(EPO)、细胞间黏附分子-1(ICAM-1)水平，并进行安全性评价。结果：观察组治疗1周和2周的创面愈合率均高于对照组，创面愈合时间短于对照组(均P<0.05)。观察组换药次数少于对照组，首次换药舒适度评分低于对照组，敷料二次创伤分级优于对照组(均P<0.05)。治疗6 d后，观察组细菌培养阳性率低于对照组(P<0.05)。治疗2周后，观察组EPO水平高于对照组，ICAM-1水平低于对照组(P<0.05)。两组不良反应发生率比较，差异无统计学意义(P>0.05)。结论：bFGF联合中性氧化电位水敷料可促进Ⅱ度烧伤创面上皮化，缩短愈合时间，提高换药舒适度。

    [关键词]Ⅱ度烧伤；创面；碱性成纤维细胞生长因子；中性氧化电位水敷料；促红细胞生成素(EPO)；细胞间黏附分子-1(ICAM-1)

    [中图分类号]R644" " [文献标志码]A" " [文章编号]1008-6455(2025)09-0056-04

    Effect of Basic Fibroblast Growth Factor Combined with Neutral Electrolyzed Oxidizing Water Dressing on Second-degree Burn Wound Healing

    XIA Yuping1， ZHANG Binbin1， HUANG Yong2， ZHANG Wenxia1

    ( 1.Department of Burn and Plastic Surgery， 2.Department of Interventional， the Fourth People's Hospital of Zigong， Zigong 643000， Sichuan， China )

    Abstract： Objective" To investigate the effect of basic fibroblast growth factor (rh-bFGF) combined with neutral electrolyzed oxidizing water dressing in promoting second-degree burn wound healing. Methods" A total of 100 patients with partial-thickness burns admitted to the author's hospital from January 2022 to February 2024 were selected as the research objects. According to the random number table method ......