新生儿脐血IL-4,IL-13,IFN-γ,TGF-β测定及其意义(1)
http://www.100md.com
2010年2月1日
 |
| 第1页 |
参见附件(1554KB，2页)。
【摘要】目的:测定并分析新生儿脐血IL-4,IL-13,IFN-γ,TGF-β的含量及其可能的危险因素,探讨脐血IL-4,IL-13,IFN-γ,TGF-β含量与6个月内婴儿发生湿疹可能性的关系。方法:用ELISA法测定72例青岛地区足月顺产健康新生儿(男性38例,女性34例)脐血IL-4,IL-13,IFN-γ,TGF-β含量,随访并记录家族过敏性疾病史、父母吸烟史、母亲孕期饮食情况、6个月内婴儿发生湿疹情况等。结果:父亲或母亲有过敏性疾病的新生儿脐血IL-13含量明显高于对照组(P<0.01),而TGF-β含量明显低于对照组(P<0.01)。父亲或母亲有过敏性疾病新生儿脐血IL-4、IFN-γ含量与对照组差别无统计学意义。父亲或母亲有吸烟史、母亲孕期回避特殊食物新生儿脐血IL-4,IL-13,IFN-γ,TGF-β因子的含量、6个月内发生湿疹的概率与对照组差别没有统计学意义。6个月内发生湿疹组婴儿脐血IL-13含量高于对照组(P<0.01),而TGF-β含量低于对照组(P<0.01),6个月内发生湿疹组婴儿脐血IL-4、IFN-γ含量与对照组差别无统计学意义。结论:父母有过敏性疾病及发生湿疹的新生儿脐血IL-13含量增高,新生儿脐血IL-13、TGF-β含量可能对预测以后湿疹等过敏性疾病的发生有一定临床意义。
【关键词】 脐血;过敏;婴儿
【中图分类号】R72 【文献标识码】A 【文章编号】1008-6455(2010)08-0035-02
【Abstract】Objective:To survey and analyze the content and the possible risk factors of IL-4,IL-13,IFN-γ,TGF-β in cord blood of new arrivals. Methods:The cord serum of 72 full-month, normal born, healthy new arrivals in qingdao were analyzed using ELISA for the content of IL-4,IL-13,IFN-γ,TGF-β including thirty eight boys and thirty four girls.The allergic diseases of parents,smoking history of parents,the diet of mothers in pregnance and the occurence of eczema of infants within 6 months were also recorded. Results:The content of IL-13 in cord serum in the group of allergic families was significantly higher than the control group (P<0.01)while the content of TGF-β in cord serum in the group of allergic families was significantly lower than the control group(P<0.01). The content of IL-4 and IFN-γ in cord serum in the allergic families had no significant difference with the control group. The smoking history of parents,the diet of mothers in pregnance didn’t have impact on the content of IL-4,IL-13,IFN-γ,TGF-β in cord serum and the occurence of eczema of infants within 6 months. The content of IL-13 in cord serum in the infants with eczema within six months was significantly higher than the control group(P<0.01)while the content of TGF-β in cord serum in the infants with eczema within six months was significantly lower than the control group(P<0 ......
您现在查看是摘要介绍页，详见PDF附件(1554KB，2页)。