[摘 要] 目的：探讨半导体激光经巩膜睫状体光凝治疗难治性青光眼的优化方案。方法：采用正交分析方法将63例难治性青光眼分为7个组，每组9个病人，选择激光功率、曝光时间、激光点数及激光范围四个因素，每个因素考虑3个水平，比较不同激光功率、曝光时间、激光点数及范围对眼压的影响，找出诸因素各水平的优化配比。结果：观察13～22个月，激光功率1.8W、曝光时间1.0S、激光点数30点、激光范围270°为优化激光参数组合；激光功率、曝光时间、激光点数是影响手术后眼压及手术前后眼压差的主要因素(P<0.05)，而激光范围是次要因素(P>0.05)。结论：半导体激光经巩膜睫状体光凝采用优化激光参数组合方案治疗难治性青光眼降低眼压疗效确切，并发症少。

    [关键词] 半导体激光；正交分析；难治性青光眼

    [Abstract] Objective To evaluate the preferred plan of transscleral diode laser cyclophotocoagulation for refractory glaucoma. Methods 63 patients were randomly divided into seven groups. Each group had nine patients.63eyes from 63 patients with refractory glaucoma underwent transscleral diode laser cyclophotocoagulation with different factors, included laser power, time, spots and range. Each factor had 3 levels. The optimum mix radio of laser factors is advanced by orthogonal analysis. Results The patients were followed 13 to 22 months. The optimum mix radio were the treatments with 1.8W for 1.0 second, 30 spots, ranging 270°. Laser power, time and spots were the main factors to IOP. IOP was significantly decreased by transscleral diode laser cyclophotocoagulation(P<0.05). The range was secondary factor(p>0.05). Conclusions Preferred plan of transscleral diode laser cyclophotocoagulation for refractory glaucoma is a safe and effective therapy. ......