论文下载：不同频率电针对切卵大鼠松质骨空间结构的影响

不同频率电针对切卵大鼠松质骨空间结构的影响(1)

http://www.100md.com 2010年4月1日金肖青1,詹红生2,石巧娟3,陈益丹1

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     收稿日期:2009-11-09

    基金项目:浙江省自然科学基金资助项目(Y206946)

    作者简介:金肖青(1963-),女,浙江人,主任医师,博士,研究方向:针刺镇痛、中医药防治骨质疏松症。

    (1.浙江医院,浙江杭州 310013;2.上海中医药大学骨伤研究所,上海 201203;

    3.浙江省医学科学院动物实验中心,浙江杭州 310012)

    摘要:目的:观察电针不同脉冲频率对切卵大鼠松质骨结构的影响,探讨电针治疗原发性骨质疏松模型大鼠的最佳刺激参数。方法:采用电针2Hz、100Hz、2/100Hz不同频率对去卵巢骨质疏松大鼠进行治疗,以倍美力灌胃作为对照组,观察Micro-CT下大鼠松质骨空间结构参数以及血清E2、PICP、ICTP的变化。结果:电针组能不同程度提高模型大鼠骨小梁数目、厚度、骨体积分数和血清E2、PICP含量,减小骨小梁间隙、骨表面积体积比,降低血清ICTP水平;其中以100Hz频率电针组疗效更为明显。结论:电针对骨质疏松大鼠骨小梁空间结构具有一定的保护作用,并且这种保护作用以100Hz频率电针刺激更为明显。

    关键词:电针;不同频率;切卵大鼠;骨空间结构

    中图分类号:R2-33 文献标识码:A 文章编号:1673-7717(2010)04-0817-03

    Effects of Electro-Acupuncture with Different Frequency on Space Structures of Cancellous Bone in the Ovariectomized Rat Model

    JIN Xiaoqing1,ZHAN Hongsheng2,SHI Qiaojuan3,CHEN Yidan1

    (1.Zhejiang Hospital,Hangzhou 310013,Zhejiang,China;

    2.Department of Orthopedics and Traumatology,Tradition Chinese Medicine Academy of Shanghai,Shanghai 201203,China;

    3.Center of Experiment Animal of Zhejiang Academy of Medicine, Hangzhou 310012,Zhejiang,China)

    Abstract:Objective: To observe the effects of electro-acupuncture with different frequency on space structures of cancellous bone in the ovariectomized rat model, and seek the optimal parameter of electro-acupuncture in treating osteoporosis in ovariectomized rat model. Methods: To treat The ovariectomized rats model with osteoporosis , electro-acupuncture groups were treatedwith 2Hz,100Hz and 2/100 Hz three different frequencies, the control group received gastric perfusion of Premarin , and investigate the parameters of cancellous bone space structures with Micro-CT, and the changes of serum estradiol (E2), carboxyterminal propeptide of type I procollagen(PICP),carboxyterminal telopeptide of type I collagen(ICTP).Results:Electro-acupuncture groups could significantly enhance trabecular number(Tb N), trabecular thickness (Tb.Th),bone volume fraction(BV/TV)and serum E2, PICP ,while trabecular spacing (Tb ......

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