论文下载：补中益气汤对封闭抗体缺乏的反复自然流产患者生殖免疫调节研究

补中益气汤对封闭抗体缺乏的反复自然流产患者生殖免疫调节研究(1)

http://www.100md.com 2010年4月1日金丽华1,叶平2,张丽2,王香桂 2

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     收稿日期:2009-11-23

    基金项目:浙江省中医药管理局资助项目 (2005B0506)

    作者简介:金丽华(1978-),女,主治医师,硕士,研究方向:中西医结合妇科内分泌。

    通讯作者:王香桂(1946-),女,主任医师、教授,硕士研究生导师,研究方向:中西医结合妇科内分泌。

    (1.浙江省新华医院,浙江杭州 310005;2.浙江省中医院,浙江杭州 310006)

    摘要:目的:观察补中益气汤为主方治疗封闭抗体缺乏的母-胎免疫识别低下型反复自然流产(Recurrent Spontaneous Abortion, RSA)患者的临床疗效。方法:以单向混合淋巴细胞反应封闭试验检测封闭抗体,选取封闭抗体缺乏的RSA患者51例,随机分成两组:一组为中药组 (治疗组),共22例,给予补中益气汤治疗;另一组为免疫组 (对照组),共29例,以配偶淋巴细胞体外诱生免疫疗法治疗,比较治疗后两组患者的封闭抗体各指标上升情况。结果:经治疗后中药组和免疫组的BE-Ab1、BE-Ab2均较治疗前明显上升(分别为P<001,P<005);但对流式细胞术分析的抗CD3-BE、抗CD4-BE及抗CD8-BE无明显改善作用(P>005)。中药组和免疫组的BE-Ab1、 BE-Ab2平均值都随着治疗次数的增加而呈逐渐上升趋势。结论:补中益气汤使可使RSA患者的BE-Ab1、BE-Ab2明显上升,并使BE-Ab1、BE-Ab2随着治疗次数的增加而逐渐上升、封闭抗体正常时妊娠成功率较缺乏时明显上升。由本研究得出:补中益气汤和配偶淋巴细胞体外诱生免疫疗法治疗RSA患者的临床疗效相近。

    关键词:补中益气汤;流产;习惯性;淋巴细胞培养试验;混合;免疫疗法;主动;流式细胞术

    中图分类号:R714.21 文献标识码:B 文章编号:1673-7717(2010)04-0827-03

    The Regulation of genito-immue on Buzhong Yiqi Tang to Recurrent Spontaneous

    Aborters of Insufficient Materno-fetal Recognition with Insufficient Blocking Antibodies

    JIN Lihua1,YE Ping2,ZHANG Li2,WANG Xianggui2

    (1.Xinhua Hospital of Zhejiang,Hangzhou 310005,Zhejiang,China;

    2.Zhejiang Hospital of TCM,Hangzhou 310006,Zhejiang,China)

    Abstract:Objective:To observe the clinic effect of Buzhong Yiqi Tang in treating recurrent spontaneous abortion(RSA) of insufficient materno-fetal recognition. with insufficient blocking antibodies.Methods:We examined blocking antibodies with One-way mixed lymphocyte culture (MLC) and divided 51 patients with insufficient blocking antibodies into two groups randomly: the treatment group and the control group. The treatment group were treated with Chinese herb:Buzhong Yiqi Tang; the control group were immunized with the in-vitro inducing paternal lymphocytes. The upgrade state of BA and the relationship between the level of BA and times of treatment after treatment were observed.Results:The level of BE-Ab1 and BE-Ab2 was increased significantly (P<0.01 and P<0.05 respectively) than before treatment, but it have not obvious improvement on anti-CD3 blocking antibodies, anti-CD4 blocking antibodies and anti-CD8 blocking antibodies in peripheral sera of the RSA patients (P﹥0 ......

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