双黄花颗粒对急性上呼吸道感染患者血清病毒含量的影响(1)

http://www.100md.com 2012年4月1日 蔡光先 贺海霞 伍参荣 王宇红 王华

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     摘 要：目的：观察双黄花颗粒对风热阻肺(卫)兼气虚证急性上呼吸道感染(病毒性感染)患者血清病毒含量的影响。方法：采用随机双盲的方法，将90例受试者按1∶1∶1的比例随机分为对照组、治疗组1及治疗组2，分别予以风热感冒颗粒、双黄花颗粒超微制剂、双黄花颗粒提取制剂，疗程为3天；用双抗体夹心酶联免疫法检测患者血清中鼻病毒(RhV)、腺病毒(ADV)及副流感病毒(HPIV)含量变化。结果：治疗前，3组患者的血清RhV、ADV、HPIV含量比较差异均无统计学意义(P>0.05)；经治疗后，治疗组1和治疗组2上述病毒含量与对照组比较差异均有统计学意义(P<0.01)，且治疗组1优于治疗组2(P<0.05)。结论：双黄花颗粒对于急性上呼吸道感染患者有一定的抗病不良反应，值得临床应用。

    关键词：双黄花颗粒；超微制剂；急性上呼吸道感染；鼻病毒；腺病毒；副流感病毒

    中图分类号：R285.6

    文献标识码：B

    文章编号：1673-7717(2012)04-0684-02

    Effect of Shuanghuanghua Particles on Serum Virus Content of Acute Upper Respiratory Infection Patients

    CAI Guang-xian1,HE Hai-xia2,WU Can-rong1，WANG Yu-hong2，WANG Hua2

    (1.Hunan University of Chinese Medicine，Changsha 410007，Hunan，China;

    2.The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，Hunan，China)

    Abstract:Objective:To observe the effect of Shuanghuanghua(SHH) Particles on serum virus content of acute upper respiratory infection patients of wind-heat blocking lung and qi deficiency. Methods：Randomized and double-blind study was carried out in 90 patients as treatment groups including control group，treatment group 1 and treatment group 2，with 30 patients for each group. Fengre Ganmao particles，Chaowei SHH particles and SHH extractive were given to the three groups respectively for three consecutively days. Then ELASA was used to detect the changes of RhV、ADV and HPIV in serum. Results：Before treatment，the the contents of the above virus of the three groups were of no statistic significance(P>0.05); after treatment，compared with the control group，the treatment group 1 and treatment group 2 were better，the difference was significant(P<0.01)，and the result of treatment group1 was superior to that of treatment group 2(P<0.05). Conclusion：Chaowei SHH particles have anti-viral action on the upper respiratory infections patients. Therefore，it is worth of clinical application.

    Key words:SHH particles；Chaowei medicaments；acute upper respiratory infection； RhV；ADV；HPIV

    急性上呼吸道感染是鼻腔、咽或喉部急性炎症的概称，其常见病原体为病毒，少数是细菌。由于病毒结构及生长环境的特殊性，抗病毒药物的研究与开发非常艰难[1]，而病毒感染性疾病却是医学界最棘手的一类疾病之一。本课题组运用自制药双黄花颗粒治疗急性上呼吸道感染(病毒性感染)60例，现将研究结果报道如下。

    1资料与方法

    1.1 一般资料 选取湖南省中医药研究院附属医院2009年9月-2010年3月门诊或急诊患者90例，随机分成对照组、治疗组1、治疗组2各30例，病程均小于或等于24h。其中对照组男15例，女15例，年龄18～56岁 ......

    http://www.100md.com/html/paper/1009-5276/2012/04/03.htm

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