p63蛋白在乳腺良恶性上皮性病变中的表达及意义(2)
本组实验还发现导管内癌周围p63阳性MECs呈异质性,有连续的,不连续的。甚至完全缺如不等。增生的导管周围有完整的MECs是良性增生的重要特征,但不是鉴别良、恶性的绝对标准,因为部分导管内癌可有完整的MECs存在。导管内癌如果其外周的MECs不完整甚至缺失,并不能说明发生浸润。一定要密切结合HE和基底膜染色,观察基底膜是否完整和间质是否有癌细胞浸润,才能对浸润有正确的判断。当然,缺乏MECs是大多数浸润癌的特点,所以某些时候MECs状况对判断原位癌还是浸润癌可能还是会有所帮助。
参考文献:
[1] Papotti M,Eusebi V,Gugliotta P,et al. Immunohistochemical analy-sis of benign and m alignant papillary lesions of the breast[J]. Am J Surg Pathol,1993,7:451.
[2] Tannishtha R,Sean J,Micheal F,et al. Stem cells cancer and cancer stem cells[J].Nature,2001,414(3):105.
[3] Barbareschi M,Pecciarini L,Cangi MG,et al. P63,a p53 homologue,is a selective nuclearmarker of myoepithelial cells of the human breast[J].Am J Surg Pathol,2001,25:1054.
[4] Werling RW,Hwang H,Yaziji H,et al. Immunohistochemical distinc-tion of invasive from noninvasive breast lesions[J]. Am J Surg Pathol,2003,27(1):82.
[5] 卢晓梅,陈书媛,张淑红. p63显示肌上皮细胞在乳腺癌诊断中的价值[J]. 临床与实验病理学杂志,2004,20(1):35.
[6] Batistatou A,Stefanou D,Arkoumani E,et al. The usefulness of p63 as a marker of breast myoepithelial cells[J]. In vivo,2003,17(6):573.
[7] Prasad ML,Hyjek E,Giri DD,et al. Double immunolabling with cy-tokeratin and smooth muscle actin in confirming early invasive carci-noma of breast[J].Am J Surg,1999,23:176.
收稿日期:2007-07-23, 百拇医药(邓星辉 余卫东 周 伟)
参考文献:
[1] Papotti M,Eusebi V,Gugliotta P,et al. Immunohistochemical analy-sis of benign and m alignant papillary lesions of the breast[J]. Am J Surg Pathol,1993,7:451.
[2] Tannishtha R,Sean J,Micheal F,et al. Stem cells cancer and cancer stem cells[J].Nature,2001,414(3):105.
[3] Barbareschi M,Pecciarini L,Cangi MG,et al. P63,a p53 homologue,is a selective nuclearmarker of myoepithelial cells of the human breast[J].Am J Surg Pathol,2001,25:1054.
[4] Werling RW,Hwang H,Yaziji H,et al. Immunohistochemical distinc-tion of invasive from noninvasive breast lesions[J]. Am J Surg Pathol,2003,27(1):82.
[5] 卢晓梅,陈书媛,张淑红. p63显示肌上皮细胞在乳腺癌诊断中的价值[J]. 临床与实验病理学杂志,2004,20(1):35.
[6] Batistatou A,Stefanou D,Arkoumani E,et al. The usefulness of p63 as a marker of breast myoepithelial cells[J]. In vivo,2003,17(6):573.
[7] Prasad ML,Hyjek E,Giri DD,et al. Double immunolabling with cy-tokeratin and smooth muscle actin in confirming early invasive carci-noma of breast[J].Am J Surg,1999,23:176.
收稿日期:2007-07-23, 百拇医药(邓星辉 余卫东 周 伟)