Caveokin-1的生物学结构及在肿瘤研究中的进展(2)
[2] Engelman JA，Zhang XL，Razani B，et al.p42/44 MAP kinase-depen-dent and -independent signaling pathways regulate caveolin-1 geneexpression.Activation of Ras-MAP kinase and protein kinase a sign-aling cascades transcriptionally down-regulates caveolin-1 promoter activity[J].J Biol Chem，1999，274(45):32333.
[3] Capozza F,Williams TM,Schubert W,et al.Absence of caveolin-1 sen-sitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation[J].Am J Pathol,2003,162(6):2029.
[4] Hayashi K，Matsuda S，Machida K,et al.Invasion activating caveolin-1mutation in human scirrhous breast cancers[J].Cancer Res,2001,61(6):2361.
[5] Tahir SA,Frolov A,Hayes TG,et al.Preoperative serum caveolin-1 as aprognostic marker for recurrence in a radical prostatectomy cohort[J].Clin Cancer Res,2006,12(16):4872.
[6] Suzuoki M,Miyamoto M,Kato K,et al.Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma[J].Br J Cancer，2002，87(10):1140.
[7] Fong A,Garcia E，Gwynn L，et al.Expression of caveolin-1 and cave-olin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation[J].Am J Clin Pathol，2003，120(1):93.
[8] Galbiati F，Volonte D，Engelman JA，et al.Targeted downregulation ofcaveolin-1 is sufficient to drive cell transformation and hyperactivatethe p42/44 MAP kinase cascade[J].EMBO J,1998, 17(22):6633.
[9] Lu Z,Ghosh S,Wang Z,et al.Downregulation of caveolin-1 function byEGF leads to the loss of E-cadherin,increased transcriptional activityof beta-catenin,and enhanced tumor cell invasion[J].Cancer Cell,2003,4(6):499.
[10] Fujita Y, Maruyama S, Kogo H, et al. Caveolin-1 in mesangial cellssuppresses MAP kinase activation and cell proliferation induced bybFGF and PDGF[J]. Kidney Int, 2004, 66(5):1794.
[11] Lee H,Woodman SE,Engelman JA,et al.Palmitoylation of caveolin-1at a single site (Cys-156) controls its coupling to the c-Src tyrosinekinase:targeting of dually acylated molecules (GPI-linked, transmem-brane，or cytoplasmic) to caveolae effectively uncouplesc-Src and caveolin-1 (TYR-14) [J].J Biol Chem，2001，276(37):35150.
[12]Liu P，Rudick M， Anderson RG.Multiple functions of caveolin-1[J].J Biol Chem，2002，277(44):41295.
收稿日期：2007-08-16修回日期：2007-08-27, 百拇医药(郑庆玲)
[3] Capozza F,Williams TM,Schubert W,et al.Absence of caveolin-1 sen-sitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation[J].Am J Pathol,2003,162(6):2029.
[4] Hayashi K，Matsuda S，Machida K,et al.Invasion activating caveolin-1mutation in human scirrhous breast cancers[J].Cancer Res,2001,61(6):2361.
[5] Tahir SA,Frolov A,Hayes TG,et al.Preoperative serum caveolin-1 as aprognostic marker for recurrence in a radical prostatectomy cohort[J].Clin Cancer Res,2006,12(16):4872.
[6] Suzuoki M,Miyamoto M,Kato K,et al.Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma[J].Br J Cancer，2002，87(10):1140.
[7] Fong A,Garcia E，Gwynn L，et al.Expression of caveolin-1 and cave-olin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation[J].Am J Clin Pathol，2003，120(1):93.
[8] Galbiati F，Volonte D，Engelman JA，et al.Targeted downregulation ofcaveolin-1 is sufficient to drive cell transformation and hyperactivatethe p42/44 MAP kinase cascade[J].EMBO J,1998, 17(22):6633.
[9] Lu Z,Ghosh S,Wang Z,et al.Downregulation of caveolin-1 function byEGF leads to the loss of E-cadherin,increased transcriptional activityof beta-catenin,and enhanced tumor cell invasion[J].Cancer Cell,2003,4(6):499.
[10] Fujita Y, Maruyama S, Kogo H, et al. Caveolin-1 in mesangial cellssuppresses MAP kinase activation and cell proliferation induced bybFGF and PDGF[J]. Kidney Int, 2004, 66(5):1794.
[11] Lee H,Woodman SE,Engelman JA,et al.Palmitoylation of caveolin-1at a single site (Cys-156) controls its coupling to the c-Src tyrosinekinase:targeting of dually acylated molecules (GPI-linked, transmem-brane，or cytoplasmic) to caveolae effectively uncouplesc-Src and caveolin-1 (TYR-14) [J].J Biol Chem，2001，276(37):35150.
[12]Liu P，Rudick M， Anderson RG.Multiple functions of caveolin-1[J].J Biol Chem，2002，277(44):41295.
收稿日期：2007-08-16修回日期：2007-08-27, 百拇医药(郑庆玲)