拉米夫定致HBV基因耐药检测方法及临床进展(2)
参考文献：
[1] Bartholomeusz A，Schaefer S.Hepatitis B virus genotypes: comparison of genotyping methods[J].Rev Med Virology，2004，14:3.
[2] Niesters HG，De Man RA，Pas SD，et al.Identification of anew variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy[J].J Med Microbiol，2002，51:695.
[3] Yang DH，Liang WF. PCR restriction fragment length polymorphism in detection of YMDD variants of viral polymerase in hepatitis B viruspatients treatedwith lamivudine[J].Hepatobiliary Pancreat Dis Int，2002，23：2.
[4] Ide T，KumashiroIde T，Kumashiro R，et al.A real-time quantitative polymerase chain reaction method for hepatitis B virus in patients with chronic hepatitis B treated with lamivudine[J]. Am J Gastroen-terol，2003，98:2048.
[5] Chieochansin T，Chutinimitkul S.Rapid detection of lamivudine-re-sistant hepatitis B virus mutations by PCR-based methods[J].Tohoku J Exp Med，2006，210:67.
[6] Zhang R，Li RC，Li YP，et al.Establishment and preliminary applica-tion of a gene chip for detection of hepatitis B virus "a" determinant hotpoint mutation[J].Zhonghua Gan Zang Bing Za Zhi，2007，15:103.
[7] Hyunjung Jang，Mong Cho，Jeong Heo，et al.Oligonucleotide chip for detection of lamivudine-resistant hepatitis B virus[J].J Clin Microbiol，2004，42: 4181.
[8] Tran N，Berne R.European multicenter evaluation of high-density DNA probe arrays for detection of hepatitis B virus resistance muta-tions and identification of genotypes[J].J Clin Microbiol，2006，44:2792.
[9] Anna S，Lok F，Brian J. McMahon. A ASLDGuidenceon Chronic Hepatitis B[J].Hepatology，2007，24:508.
[10] Thompson AJ，Ayres A，Yuen L，et al.Lamivudine resistance in pa-tients with chronic hepatitis B: role of clinical and virological fac-tors[J]. J Gastroenterol Hepatol，2007，22:1078.
收稿日期：2008-03-31, 百拇医药(赵敦勇 张大志)
[1] Bartholomeusz A，Schaefer S.Hepatitis B virus genotypes: comparison of genotyping methods[J].Rev Med Virology，2004，14:3.
[2] Niesters HG，De Man RA，Pas SD，et al.Identification of anew variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy[J].J Med Microbiol，2002，51:695.
[3] Yang DH，Liang WF. PCR restriction fragment length polymorphism in detection of YMDD variants of viral polymerase in hepatitis B viruspatients treatedwith lamivudine[J].Hepatobiliary Pancreat Dis Int，2002，23：2.
[4] Ide T，KumashiroIde T，Kumashiro R，et al.A real-time quantitative polymerase chain reaction method for hepatitis B virus in patients with chronic hepatitis B treated with lamivudine[J]. Am J Gastroen-terol，2003，98:2048.
[5] Chieochansin T，Chutinimitkul S.Rapid detection of lamivudine-re-sistant hepatitis B virus mutations by PCR-based methods[J].Tohoku J Exp Med，2006，210:67.
[6] Zhang R，Li RC，Li YP，et al.Establishment and preliminary applica-tion of a gene chip for detection of hepatitis B virus "a" determinant hotpoint mutation[J].Zhonghua Gan Zang Bing Za Zhi，2007，15:103.
[7] Hyunjung Jang，Mong Cho，Jeong Heo，et al.Oligonucleotide chip for detection of lamivudine-resistant hepatitis B virus[J].J Clin Microbiol，2004，42: 4181.
[8] Tran N，Berne R.European multicenter evaluation of high-density DNA probe arrays for detection of hepatitis B virus resistance muta-tions and identification of genotypes[J].J Clin Microbiol，2006，44:2792.
[9] Anna S，Lok F，Brian J. McMahon. A ASLDGuidenceon Chronic Hepatitis B[J].Hepatology，2007，24:508.
[10] Thompson AJ，Ayres A，Yuen L，et al.Lamivudine resistance in pa-tients with chronic hepatitis B: role of clinical and virological fac-tors[J]. J Gastroenterol Hepatol，2007，22:1078.
收稿日期：2008-03-31, 百拇医药(赵敦勇 张大志)