GATA-4、NKx2-5转录因子的研究进展(3)
[12] Kasahara H，Lee B，Schott JJ，et al.Less of function and inhibitory effects of human CSX/NKx215 homeop rotein mutations associated with congenital heart disease[J].J Clin Invest，2000，106: 299.
[13] Kasahara H，Usheva A，Ueyama T，et al. Characterizationof homo and heterodimerization of cardiac Csx/ Nkx2.5 homeoprotein[J].J BiolChem，2001，276 (7):4 570280.
[14] Bodmer R.The gene tinman is required for specification of the heartand visceral muscles in Drosophila[J]. Development，1993，118 (3):719229.
[15] Lyons I，Parsons LM，Hartley L，et al.Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5[J].Genes Dev，1995，9 (13) : 1654266.
[16] Scohtt JJ，Benson DW，Basson CT， et al.Congenital heart disease caused by nutations in the transcription factor NKX2-5[J].Science，1998，281(5 373) :108211.
[17] Stennard FA，Costa MW， Elliott DA，et al.Cardiac Tbox factor Tbx20directly interacts with Nkx2-5，GATA-4，andGATA5 in regu lation of gene expression in the developing heart[J].Dev Biol，2003，262(2):206224.
[18] Hirota Y，Sawamoto K，Okano H.tincar encodes a novel transmem-brane protein expressed in the Tinman-expressing cardioblasts of Drosophila[J].Gene Expr Patterns，2002，2(3~4):323.
收稿日期：2008-01-16 修回日期：2008-03-31, http://www.100md.com(冉 莉 文格波)
[13] Kasahara H，Usheva A，Ueyama T，et al. Characterizationof homo and heterodimerization of cardiac Csx/ Nkx2.5 homeoprotein[J].J BiolChem，2001，276 (7):4 570280.
[14] Bodmer R.The gene tinman is required for specification of the heartand visceral muscles in Drosophila[J]. Development，1993，118 (3):719229.
[15] Lyons I，Parsons LM，Hartley L，et al.Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5[J].Genes Dev，1995，9 (13) : 1654266.
[16] Scohtt JJ，Benson DW，Basson CT， et al.Congenital heart disease caused by nutations in the transcription factor NKX2-5[J].Science，1998，281(5 373) :108211.
[17] Stennard FA，Costa MW， Elliott DA，et al.Cardiac Tbox factor Tbx20directly interacts with Nkx2-5，GATA-4，andGATA5 in regu lation of gene expression in the developing heart[J].Dev Biol，2003，262(2):206224.
[18] Hirota Y，Sawamoto K，Okano H.tincar encodes a novel transmem-brane protein expressed in the Tinman-expressing cardioblasts of Drosophila[J].Gene Expr Patterns，2002，2(3~4):323.
收稿日期：2008-01-16 修回日期：2008-03-31, http://www.100md.com(冉 莉 文格波)