氯吡格雷和他汀联用对急性冠脉综合征患者临床观察(2)
本研究认为常规用量的他汀，不管是否经过CYP 3A4代谢，与氯吡格雷联合应用都是安全的 。但本 研究中例数较少应用的他汀也为常规剂量，两种药物之间的相互作用是否会对临床事件产生 影响和确切结论尚需进一步研究。
参考文献
[1]Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ab ility of clopidogrel to inhibit platelet aggregation: a new drug_drug interactio n[J]. Circulation, 2003,107(1):32-37.
[2]Transon C, Leemann T, Vogt N, et al. In vivo inhibition profile of cytochro me P450TB(CYP2C9) by(+/-)_fluvastatin[J]. Clin Pharmacol Ther, 1995,58(4):41 2-417.
[3]Saw J, Steinhubl SR, Berger PB, et al. Lack of adverse clopidogrel_atorvast atin clinical interaction from secondary analysis of a randomized, placebo_contr olled clopidogrel trial[J]. Circulation, 2003,108(8):921-924.
[4]Saw J, Brennan DM, Steinhubl SR, et al. Lack of evidence of a clopidogrel_s tatin interaction in the CHARISMA trial[J]. J Am Coll Cardiol, 2007,50(4):291 -295.
[5]Muller I, Besta F, Schulz C, et al. Effects of statins on platelet inhibiti on by a high logding dose of clopidogrel[J]. Circulation, 2003,108(18):2195-2 197.
[6]Mitsios JV, Papathanasiou AI, Rodis FI, et al. Atorvastatin does not affect
the antiplatelet potency of clopidogrel when it is administered concomitantly f or 5 weeks in patients with acute coronary syndromes[J]. Circulation, 2004,109 (11):1335-1338., 百拇医药(赵 嫣 屈百鸣 丁亚辉 俞坚武 车贤达)
参考文献
[1]Lau WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ab ility of clopidogrel to inhibit platelet aggregation: a new drug_drug interactio n[J]. Circulation, 2003,107(1):32-37.
[2]Transon C, Leemann T, Vogt N, et al. In vivo inhibition profile of cytochro me P450TB(CYP2C9) by(+/-)_fluvastatin[J]. Clin Pharmacol Ther, 1995,58(4):41 2-417.
[3]Saw J, Steinhubl SR, Berger PB, et al. Lack of adverse clopidogrel_atorvast atin clinical interaction from secondary analysis of a randomized, placebo_contr olled clopidogrel trial[J]. Circulation, 2003,108(8):921-924.
[4]Saw J, Brennan DM, Steinhubl SR, et al. Lack of evidence of a clopidogrel_s tatin interaction in the CHARISMA trial[J]. J Am Coll Cardiol, 2007,50(4):291 -295.
[5]Muller I, Besta F, Schulz C, et al. Effects of statins on platelet inhibiti on by a high logding dose of clopidogrel[J]. Circulation, 2003,108(18):2195-2 197.
[6]Mitsios JV, Papathanasiou AI, Rodis FI, et al. Atorvastatin does not affect
the antiplatelet potency of clopidogrel when it is administered concomitantly f or 5 weeks in patients with acute coronary syndromes[J]. Circulation, 2004,109 (11):1335-1338., 百拇医药(赵 嫣 屈百鸣 丁亚辉 俞坚武 车贤达)