中图分类号:R541.4 文献标 识码:A 文章编号:1009_816X(2010)04_0265_03

    DOI:10.3969/j.issn.1009_816X.2010.04.05

    Study on Plasma Level of Macrophage Migration Inhibitory Factor(MIF) and Tumor N ecrosis Factor_α (TNF_α)in Patients with Acute Coronary Syndrome(ACS). HUANG Yi_wei, WANG Jun, ZENG Xiang_cun, et al. Department of Cardiology, Wenzho u No.2 people's hospital, Zhejiang 325000 China

    [Abstract] ObjectiveTo observe plasma MIF and TNF_α levels in patients with AC S and explore their clinical significance in ACS.Methods 58 patients with ACSwere recruited, including 30 patients with acute myocardial infarction(AMI)and 2 8 patients with unstable angina(UA), 24 cases who had normal coronary angiograph y also were recruited as control group. The degree of coronary artery stenosis w as determined by Gensini's scores system. Plasma MIF level was measured by ELISAand TNF_α was measured by radioimmunoassay (RIA) method.Results The levels ofMIF and TNF_α in ACS group were significantly higher than those in control gro up(P<0.01), and they were higher in AMI subgroup than in UA subgroup(P <0.01). The levels of MIF、TNF_α in ACS group were correlated with the degreeof coronary artery stenosis(P<0.05).Conclusions Increased MIF and TNF_α could not o nly reflect the severity of ACS, but also predict the potential risk and the deg ree of coronary artery stenosis in the initial stage of ACS. ......