【摘要】 子宫腺肌病是一种常见的妇科疾病，严重影响女性生育健康，其特征是子宫内膜异位至子宫肌层，导致疼痛和不孕。近年来，研究发现上皮-间质转化(EMT)在此病发生发展中起着关键作用。EMT是一个复杂的生物学过程，其中黏着斑激酶通过Hippo-YAP轴参与上皮间质转化，从而使得上皮细胞获得间质细胞特性，参与组织修复和肿瘤侵袭转移。在子宫腺肌症中，EMT可能导致细胞粘附性降低和侵袭能力增强，从而促进病灶形成和扩散。

    【关键词】 子宫腺肌病；子宫内膜；黏着斑激酶(FAK)；上皮间质转化;Hippo-YAP通路

    中图分类号 R711.71 文献标识码 A 文章编号 1671-0223(2025)01--03

    Research progress on epithelial mesenchymal transition in adenomyosis Jiang Wenjing， Fu Dan， Chen Mingcui， Wu Juanjuan， Jiang Min. Yangzhou University School of Medicine， Yangzhou 215009， China

    【Abstract】 Adenomyopathy is a common gynecological disease that seriously affects the reproductive health of women and is characterized by endometriosis into the myometrium， resulting in pain and infertility. In recent years， it has been found that epithelial-mesenchymal transition (EMT) plays a key role in the occurrence and development of this disease. EMT is a complex biological process， in which focal adhesion kinase (FAK) is involved in epithelial mesenchymal transition through Hippo Yap axis， which enables epithelial cells to acquire mesenchymal characteristics and participate in tissue repair and tumor invasion and metastasis. In adenomyosis ......