【摘要】" 急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)发病病因和机制复杂，病死率高居不下，目前尚无特效的治疗药物。最近研究发现，Wnt/β-catenin信号通路在ALI/ARDS中具有重要作用，如可减轻炎症反应及氧化应激、调节凝血和纤溶系统、调控细胞凋亡及铁死亡，从而达到减轻肺损伤的目的。深入研究Wnt/β-catenin信号通路在ALI/ARDS发病机制中的作用，可为ALI/ARDS的临床治疗提供新方向和策略。

    【关键词】" Wnt/β-catenin信号通路；急性肺损伤；急性呼吸窘迫综合征

    中图分类号" R563" "文献标识码" A" " 文章编号" 1671-0223(2024)12--03

    Research progress of Wnt/β-catenin signaling pathway in acute lung injury/acute respiratory distress syndrome" Yan Fan， Ke Yuxian， Jiang Yi. Chengdu Medical College; Department of Respiratory Critical Care Medicine， First Affiliated Hospital of Chengdu Medical College; Key Laboratory of Geriatic Respiratory Diseases of Sichuan Higher Education Institutes， Chengdu 610000，China

    【Abstract】" Acute lung injury/acute respiratory distress syndrome (ALI/ARDS)" has complicated etiology and mechanism， and the mortality rate remains high. At present， there is no specific therapeutic drug. It has been found that Wnt/β-catenin signaling pathway can alleviate inflammatory reaction and oxidative stress ......