Colo205来源大肠癌始动细胞分转移相关基因的表达分析(1)
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【摘要】目的 获得大肠癌始动细胞转移相关基因表达变化谱,其细胞生物学特性研究提供依据。方法 采用无血清悬浮培养、CD133抗体标记磁珠分选Colo205不同细胞群,体外分化实验及裸鼠成瘤实验鉴定细胞特性,表达谱测序分析转移相关基因表达变化。结果:3种细胞群中有14种癌症转移相关基因发生显著地表达改变。 结论:无血清培养基培养结合CD133磁珠分选Colo205细胞获得的CD133+细胞亚群具备大肠癌干细胞的基本特征且有14种转移相关基因表达发生显著改变,可用于后续生物学特性研究。
【关键词】始动细胞;大肠癌;表达谱测序;转移基因
Abstract: Objective To obtain differential genes for research of colorectal cancer initiating cells biological behavior. Methods Initiating cells were sorted by by CD133 microbead kit and RNA-seq was employed for analysis of differential genes. Results Expression levels of 14 metastatic genes were changed on the levels of mRNA ......
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