5-HT1A受体对癫痫伴发抑郁的影响及神经保护研究(3)
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综上所述，氯化锂-匹罗卡品诱发的颞叶癫痫模型可以作为癫痫伴发抑郁模型，也可以用于抗癫痫药物的筛选，8-OH-DPAT作为5-HT1A受体激动剂不但使抑郁学指标明显改善，起到抗抑郁的作用，而且通过对抗神经元凋亡和胶质细胞增生起到明显的抗癫痫的作用，为癫痫伴发抑郁提供了新的治疗方向。
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[10] 金艳 ......
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