中药序贯治疗高龄老年非ST段抬高急性冠脉综合征的临床研究(1)
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摘要:目的 研究中药序贯治疗对高龄老年非ST段抬高急性冠脉综合征(NSTEIACS)的改善作用及安全性。方法 将入选高龄老年NSTEIACS 患者57例随机分为两组，治疗组29例，对照组28例。对照组予常规西医治疗，治疗组在对照组治疗基础上，采用中药序贯治疗，先予活血祛瘀之丹红注射液，而后改用益气滋阴之参麦注射液，分别使用15 d，共30 d。检测血栓相关指标、纤维蛋白原(Fg)，对心电图ST段变化及心绞痛疗效指标进行评价；并跟踪随访3个月，观察两组心血管事件。结果 治疗组血栓相关指标及Fg下降程度明显优于对照组(P<0.05)，心电图NST及ΣST改善及心绞痛疗效优于对照组(P<0.05)，随访期间治疗组反复心绞痛(AP)发作、心力衰竭(HF)、心律失常及非致死性心肌梗死(MI)发生率较对照组减低(P<0.05)。结论 中药序贯治疗能促进老年NSTEIACS患者的心肌再灌注，有效缓解心绞痛症状，减少心脏事件发生，安全性好，无严重不良反应。
关键词:中药序贯治疗；非ST段抬高急性冠脉综合征；老年人
中图分类号：R541.4 R256.2 文献标识码：B 文章编号：16721349(2012)08092103
Chinese Herbal Medicine Sequential Therapy for Elderly NonSTsegment Elevation Acute Coronary Syndrome
Xiao Mingsheng，Cheng Yahui // 94 th Hospital of PLA(Nanchang 330002)
Abstract：Objective To study the effect and safety of Chinese herbal medicine sequential therapy on the elderly nonSTsegment elevation acute coronary syndrome (NSTEACS).Methods Fiftyseven elderly patients (pts) with NSTEACS were randomly divided into treatment group (n=29) treated with Danhong injection and Shenmai injection，and control group (n=28) treated with conventional western medicine treatment.Emboli index and fibrinogen(Fg)were tested.ECG STsegment was evaluated.Angina pectoris indicators and the cardiovascular events were observed for 3 months.Results Thrombosisrelated indicators and FG in treatment group were decreased significantly than that in control group (P<0 05).ECG NST，ΣST，and the improvement of angina in treatment group was better than that in control group (P<0.05).The angina attack，heart failure，cardiac arrhythmias，and nonfatal myocardial infarction were decreased in the treatment group during the followup 3 months (P<0 ......
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