·经验交流·

    培哚普利联合坎地沙坦治疗慢性心力衰竭及对氧化指标的影响

    赵印印

    摘要：目的探讨培哚普利联合坎地沙坦治疗慢性心力衰竭的临床疗效和对氧化应激指标的影响。方法选取2010年9月—2014年3月收治的慢性心力衰竭患者112例。随机均分为对照组和治疗组，对照组进行常规治疗；治疗组使用培哚普利联合坎地沙坦进行治疗。观察两组患者的总体疗效、心功能、左心室形态、活动能力、氧化指标、药物安全性。结果治疗后治疗组显效率(37.50%)和总有效率(82.14%)，均明显高于对照组(P0.05)。结论培哚普利联合坎地沙坦治疗慢性心力衰竭效果显著，可改善患者心功能，减轻氧化应激损伤。

    关键词：慢性心力衰竭；培哚普利；坎地沙坦；氧化应激

    中图分类号：R541R289

    收稿日期：(2014-08-13)

    Effects of Perindopril and Candesartan on the Oxidative Stress in Chronic Heart Failure

    Zhao Yinyin

    Deparment of Vasculocardiology，County Hospital of Binxian， Xianyang 713500， China

    Abstract：ObjectiveTo investigate the clinical effect and oxidative stress of perindopril and candesartan for treatment of chronic heart failure(CHF).MethodsOne hundred and twelve patients with CHF were randomly divided into two groups：Control group treated with conventional treatment，and experimental group treated with perindopril and candesartan.The total effective rates， heart function， morphology of left ventricular， activity of living， oxidative activity and drug safety were compared.ResultsThe total effective rate was 82.14% in experimental group ......