AbstractObjective：ToxplorethemechanismofhawthoextractregulatingTcelimmunityandiidmetabolisminhyperideic mice.Methods：Sixty healthymale6-weekoldspecicpathogenic(SPF)gradeC57BL/6Jmicewereadaptivelyraisedforoneweekand thenrandomly divided into the normal control group，high-fat diet(HFD) group，HFD + high-dose hawthorn extract group，HFD+mediumdosehawthomextractgroup，HFDlow-dosehawthomextractgroupandHFDatorvastatingroup.Thenormalcontrolgroupwasgiven ordinary feed andraised normaly for8weeks，while the mice in the HFDgroup were fed with high-fatfeed powered by 60% fat for 8 weks.MiceintheHFDhigh-dosehawthomextractgroup，HDmedium-dosehawthomextractgroup，ndHFDlow-dosehawthom extract group were gavaged with 5.2，2.6，and 1.3g/kg hawthorn extract，respectively after 4weeks of high-fat rearing，once a day.Mice in theatorvastatin groupwere given oraladministration of atorvastatinat a dose of 10mg/kg bygavageafter4weeksof high-fat feeding， onceaday.Thecontrolgroupandthe HFDgroupweregavagedwiththesamevolumeof normalsalineatthesamevolume.The intervention period was 4weeks.The mRNA and protein expression levels of CD₃₆ and peroxidase proliferation-activated receptor γ (PPARγ) weredetected by WestemBlotand reverse transcription polymerasechain reaction(qRT-PCR).Flowcytometry was used to detecthepropiosa)el)neli mice.Results：Compared with the normal group ......