TheMechanismGualouXiebaiBanxiaDecoctionforTreatingCoronary MicrovascularDiseaseHyperidemiabyTreating Different Diseases with Same Method \" Based on Network Pharmacology Molecular Docking JU Tongtong1，HU Jiqiang2

    1.BejingUniveitediieninoangspitalnsityfei

    100071，China

    CorrespondingAuthorHU Jiqiang，E-mail：hujiqiang0923 @ 163.com

    AbstractObjective：ToexplorethematerialbasismechanismGualouXiebaiBanxiaDecoctionfortreatingcoronarymicrovascular disease(CMVD)hyperlipidemia(HLP)by\"treatingdiferentdiseaseswithsamemethod\"basedonnetworkpharmacology moleculardockingtechnologyMethods：TheactiveingredientstargetsGualouXiebaiBanxiaDecoctionwereobtainedusingthe TraditionalChinese SystemPharmacologyDatabaseAnalysisPlatfom(TCMSP)Query therelevantargetsCMVD HLPwerescreened by GeneCardsOMIMdatabases.The Vennmapwasconstructed toobtain tecommon targetsGualou Xiebai BanxiaDcoctionwithCMVDHLP.Thenetworkdiagram\"GualouXiebaiBanxiaDecoction-activeingredients-commontargets\" wasdranbyCytoscape3.10.0starethecoreactiveingredientswerescreened.TheSTRINGdatabasewasusedtoconstruct theprotein-proteininteraction(PPl)networktoscreenthecoretargets.TheDAVIDdatabasewasusedtoconductgeneontology(G) functionalenrichmentanalysisKyoto EncyclopediaGenesGenomes(KEGG)pathwayenrichmentanalysisoncommongenes. ThecoreactiveingredientswereanalyzedformoleculardockingwiththecoretargetsusingtheAutoDockVina1.5.7stwareResults：A tota35mainctiveingredientsalouebaiBniacoctioereainednd3orectieingredientsuchssteol quercetin ......