doi：10.12102/j.issn.1672-1349.2025.14.005

    TheMechanismof Ginseng-Poria Medicinal CombinationforTreatingAlzheimersDisease BasedonNetworkPharmacologyand Molecular Docking Technology

    ZHOUMengling1，WANG Yanli'，YUBoru2

    1.BejingHspiaofdeiaiaicaitjnasci UniversityofTraditionalChineseMedicine，Tianjin3ooo73，China

    Corresponding Author YU Borui，E-mail：yu_borui@ 163.com

    AbstractObjective：ToexplorethemechanismsofGinseng-PoriamedicinalcombinationforthetreatmentofAlzheimersdisease(AD) Basedonetworkpharmacologyandmoleculardockingtechnology.Methods：TheactivecomponentsofGinseng-Poriamedicinal combinationwerepredictedandscreenedundertheconditionsoforalbioavalabilty(OB)anddrug-ikenessDL)usingtheTradional ChineseMedicineSystemPharmacologyTechnologyPlatform(TCMSP)TheactiontargetsrelatedtothetreatmentofADwerecolected throughtheGeneCardsdatabase.Thecomponent-targetandtarget-proteininteractionnetworkdiagramswereconstructedusingthe DAVIDdatabaseandCytoscape3.8.2software.Thetarget geneswereanalyzedforgeneontology(GO)functional enrichmentanalysis andKyotoEncyclopediaofGenesandGenomes(KEGG)pathwayenrichmentanalysis ......