【摘 要】 目的:研究呋喃唑酮对雄性大鼠睾丸细胞的药理作用。方法:按不同时间间隔,每日给大鼠灌喂20mg/ml呋喃唑酮,然后取大鼠睾丸进行病理细胞分析;及停药后大鼠睾丸细胞的恢复。结果:呋喃唑酮对睾丸细胞有特异性的损伤,停药一定时间细胞的功能恢复。结论:呋喃唑酮使用的剂量和时间有量效关系。

    【关键词】 呋喃唑酮; 大鼠; 睾丸

    The Furazolidone evades to the male big mouse nurtures mechanism’s research

    DONG Chun’e Jilin Province Population Life Science Research Institute, Jilin 130041, China

    【Abstract】 Objectives: The purpose of study is that Furazolidone on male rat testis cells in pharmacology. Method: According to different time-gap, daily to rats fed 20mg/ml Furazolidone, then take the rat testis pathological cell analysis; And after the restoration of rat testicular cells. Results: Furazolidone to testicle cell has the specificity damage stops the medicine certain time cell’s function restoration. Conclusion: The use dosage and the time of Furazolidone have the quantity effect relations.

    【Key words】 Furazolidong; Rat; Testes

    呋喃唑酮[nitrofurazolidone,NFZ,N-(5-nitro-2-furfuylidene)-3aminiooxazolin-2-one]属于硝基呋喃类化合物,是一种廉价的广谱抗生素[1],主要适用于治疗菌痢、腹泻[2] ......