【摘 要】：炎性肌病患者存在IL-6表达异常，病理状态下肌肉中IL-6可能主要由浸润的单核巨噬细胞产生。IL-6可能通过JAK/STAT通路调控卫星细胞的增殖分化，影响肌肉代谢导致肌萎缩，拮抗IL-6/STAT通路的治疗可能在肌病治疗中有效。

    【关键词】：IL-6;炎性肌病;肌萎缩;卫星细胞

    Abstract：Abnormal expression of IL-6 was observed in inflammatory myopathies. IL-6 was mainly expressed by infiltrating monocytes and macrophages. IL-6 can modulate the proliferation and differentiation of satellite cell through JAK/STAT pathway， and interfere protein metabolism thus lead to muscle atrophy. Treatment target IL-6/STAT pathway may be useful in myopathies.

    Key words： IL-6; inflammatory myopathy; muscle atrophy; satellite cell

    【中图分类号】R592 【文献标识码】A 【文章编号】1672-3783(2019)06-03--01

    白细胞介素6(IL-6)是一种多功能的细胞因子 ......