PINK1/Parkin-directed mitophagy pathway:A mechanistic linkage in Parki(3)
[2]Clark, I. E. et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with Parkin. Nature 441, 1162–1166, 2006.
[3]Darios F, Corti O, Lucking CB, Hampe C, Muriel MP, Abbas N, Gu WJ, Hirsch EC, Rooney T, Ruberg M et al. Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria–dependent cell death. Hum Mol Genet 12:517–526, 2003.
[4]Exner, N. et al. Loss‑of‑function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin. J. Neurosci. 27, 12413–12418, 2007.
, http://www.100md.com
[5]Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D,Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G PLoS ONE 4:e5777, 2009.
[6]Kim Y et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.Biochem. Biophys. Res. Commun. 377, 975–980, 2008.
, 百拇医药
[7]Kitada T, Asakawa S, Hattori N, et al. Mutations in the Parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 392:605– 608, 1998.
[8]Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y & Hattori N Parkin is associated with cellular vesicles. J Neurochem 78, 42–54, 2001.
[9]Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795–803, 2008.
, http://www.100md.com
[10]Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by Parkin. Nature 441, 1157–1161, 2006.
[11]Poole, A. C. et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl Acad. Sci. USA 105, 1638–1643 , 2008.
[12]Rintoul, G.L. and Reynolds, I.J. Mitochondrial trafficking and morphology in neuronal injury. Biochim. Biophys. Acta, 1802, 143–150.
, 百拇医药
[13]Rogaeva, E. et al. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch. Neurol. 61, 1898–1904, 2004.
[14]Saskia Villinger et al. Functional dynamics in the voltage-dependent anion channel. J . pnas.vol. 107 no. 52 22546-22551, 2010.
[15]Savitt, J. M., Dawson, V. L. & Dawson, T. M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J. Clin. Invest. 116, 1744–1754, 2006.
, http://www.100md.com
[16]Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K et al. Familial Parkinson disease gene product, Parkin, is a ubiquitin–protein ligase. Nat Genet 3, 302–305, 2000.
[17]Shiba, K. et al. Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383, 331–335, 2009.
[18]Sven Geisler, Kira M. Holmström, Diana Skujat, Fabienne C. Fiesel, Oliver C. Rothfuss, Philipp J. Kahle and Wolfdieter Springer. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nature cell biology, 119-131, 2011.
, http://www.100md.com
[19]Valente EM et al. Hereditary early–onset Parkinson’s disease caused by mutations in PINK1. Science 304: 1158–1160, 2004.
[20]Valente EM, Abou–Sleiman PM, Caputo V et al. Hereditary early onset Parkinson’s disease caused by mutations in PINK1. Science 304:1158 –1160, 2004.
[21]Xiong, H. et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119: 650–660, 2009.
[22]Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H, Lu B. Proc Natl Acad Sci USA 103:10793–10798, 2006., http://www.100md.com(Yingqing Du)
[3]Darios F, Corti O, Lucking CB, Hampe C, Muriel MP, Abbas N, Gu WJ, Hirsch EC, Rooney T, Ruberg M et al. Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria–dependent cell death. Hum Mol Genet 12:517–526, 2003.
[4]Exner, N. et al. Loss‑of‑function of human PINK1 results in mitochondrial pathology and can be rescued by Parkin. J. Neurosci. 27, 12413–12418, 2007.
, http://www.100md.com
[5]Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D,Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G PLoS ONE 4:e5777, 2009.
[6]Kim Y et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.Biochem. Biophys. Res. Commun. 377, 975–980, 2008.
, 百拇医药
[7]Kitada T, Asakawa S, Hattori N, et al. Mutations in the Parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 392:605– 608, 1998.
[8]Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y & Hattori N Parkin is associated with cellular vesicles. J Neurochem 78, 42–54, 2001.
[9]Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795–803, 2008.
, http://www.100md.com
[10]Park, J. et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by Parkin. Nature 441, 1157–1161, 2006.
[11]Poole, A. C. et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl Acad. Sci. USA 105, 1638–1643 , 2008.
[12]Rintoul, G.L. and Reynolds, I.J. Mitochondrial trafficking and morphology in neuronal injury. Biochim. Biophys. Acta, 1802, 143–150.
, 百拇医药
[13]Rogaeva, E. et al. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch. Neurol. 61, 1898–1904, 2004.
[14]Saskia Villinger et al. Functional dynamics in the voltage-dependent anion channel. J . pnas.vol. 107 no. 52 22546-22551, 2010.
[15]Savitt, J. M., Dawson, V. L. & Dawson, T. M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J. Clin. Invest. 116, 1744–1754, 2006.
, http://www.100md.com
[16]Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K et al. Familial Parkinson disease gene product, Parkin, is a ubiquitin–protein ligase. Nat Genet 3, 302–305, 2000.
[17]Shiba, K. et al. Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383, 331–335, 2009.
[18]Sven Geisler, Kira M. Holmström, Diana Skujat, Fabienne C. Fiesel, Oliver C. Rothfuss, Philipp J. Kahle and Wolfdieter Springer. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nature cell biology, 119-131, 2011.
, http://www.100md.com
[19]Valente EM et al. Hereditary early–onset Parkinson’s disease caused by mutations in PINK1. Science 304: 1158–1160, 2004.
[20]Valente EM, Abou–Sleiman PM, Caputo V et al. Hereditary early onset Parkinson’s disease caused by mutations in PINK1. Science 304:1158 –1160, 2004.
[21]Xiong, H. et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119: 650–660, 2009.
[22]Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H, Lu B. Proc Natl Acad Sci USA 103:10793–10798, 2006., http://www.100md.com(Yingqing Du)