老年糖尿病合并肝硬化患者白蛋白相关生化指标检验的临床意义研究(1)

http://www.100md.com 2017年7月1日 糖尿病新世界 2017年第13期

     DOI：10.16658/j.cnki.1672-4062.2017.13.003

    [摘要] 目的 探讨老年糖尿病合并肝硬化患者白蛋白相关生化指标检验的临床意义。 方法 选取2016年1月—2017年3月于该院就诊的老年糖尿病合并肝硬化患者122例，给予相应治疗，分别于干预后1、2、3周检测患者血清中ALB、PA水平，同时评估糖尿病合并肝硬化患者治疗效果。采用溴甲酚氯法检测ALB，免疫比浊法检测PA。 结果 干预后1周有效者18例，无效者104例；第2周有效者40例，无效者82例；第3周有效者85例，无效者37例。干预前及干预后1、2、3周老年糖尿病合并肝硬化患者ALB均差异无统计学意义(P>0.05)。和干预前及干预后1周相比，干预后2、3周PA显著上升(P<0.05)。结论 检测老年糖尿病合并肝硬化患者ALB、PA水平有助于评估患者治疗疗效。

    [关键词] 糖尿病合并肝硬化；老年；血清白蛋白；前白蛋白

    [中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2017)07(a)-0003-03

    Clinical Significance of Serum Albumin Related Biochemical Indexes in Elderly Patients of Diabetes Mellitus Complicated with Liver Cirrhosis

    ZHAO Yuan-xun， ZHENG Yan-qing， ZHANG Jia-qin， HONG Guo-lin

    Department of Clinical Laboratory， the First Affiliated Hospital of Xiamen University， Xiamen， Fujian Province， 361003 China

    [Abstract] Objective This paper tries to investigate the clinical significance of serum albumin related biochemical indexes in elderly patients with diabetes mellitus complicated with liver cirrhosis. Methods 122 cases of elderly patients with diabetes mellitus complicated with liver cirrhosis treated in this hospital from January 2016 to March 2017 were selected and were given corresponding treatment， the ALB， the levels of serum PA detection respectively in one week， 2 weeks and 3 weeks after treatment and the curative effect were evaluated. ALB was detected by bromine chloride， and PA was detected by turbidimetric immunoassay. Results One week after treatment， 18 cases were effective， 104 cases were invalid； 40 cases were effective， 82 cases were invalid in second week； 85 cases were effective， 37 cases were invalid in third weeks. There was no significant difference in ALB between before intervention and one， two and three weeks after treatment (P>0.05). Compared with that before intervention and one week after treatment， PA increased significantly in the second and third week (P<0.05). Conclusion The detection of ALB and PA levels in elderly patients with diabetes mellitus complicated with cirrhosis is helpful to evaluate the therapeutic efficacy of patients.

    [Key words] Diabetes mellitus complicated with liver cirrhosis； Elderly； Serum albumin； Prealbumin

    隨着人们生活方式的改变及饮食结构的变化，糖尿病的发病率逐年提高，老年是糖尿病的高发人群。我国是肝炎大国，特别是乙肝，发病率高于国际水平。由于病毒的持续存在，在反复的肝脏炎症坏死的刺激下引起再生修复及肝星状细胞的不断活化，肝细胞外基质出现异常沉积而纤维化，最终造成糖尿病合并肝硬化[1-2]。糖尿病合并肝硬化如不得到及时有效的干预后果较严重，容易导致肝癌甚至死亡[3-4]。因此临床应重视糖尿病合并肝硬化的诊断、病情评估及预后。血清白蛋白(Serum albumin，ALB)、前白蛋白(Prealbumin，PA)是反馈肝脏储备功能的指标[5]。鉴于以上认识，该研究选取2016年1月—2017年3月于该院就诊的老年糖尿病合并肝硬化患者122例作为研究对象，检测老年糖尿病合并肝硬化患者ALB、PA水平，现报道如下。(赵元勋 郑燕青 张加勤 洪国粦)

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