血脂水平与类风湿关节炎伴2型糖尿病患者疾病活动程度的影响(1)
[摘要] 目的 探讨血脂水平与类风湿关节炎伴2型糖尿病患者疾病活动程度的影响。方法 收集2016年1月—2018年5月类风湿关节炎伴2型糖尿病的50例患者，定义为研究组。选择单纯2型糖尿病的50例患者作为对照组。对比两组血脂、血糖水平对比；两组血清炎症指标水平。 结果 对照组总胆固醇、甘油三酯、低密度脂蛋白、空腹血糖、糖化血红蛋白水平明显低于研究组，比较差异有统计学意义(P<0.05)；研究组和对照组高密度脂蛋白比较差异无统计学意义(P>0.05)；研究组CRP及ESR水平明显高于对照组，比较差异有统计学意义(P<0.05)。结论 类风湿关节炎伴2型糖尿病患者血脂水平及血糖水平低于单纯2型糖尿病患者，可能与体内高水平炎症状态有关。
[关键词] 血脂；类风湿关节炎；2型糖尿病
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2018)07(a)-0048-02
Effect of Blood Liquid Level on the Disease Activity Degree of Patients with Rheumatoid Arthritis with Type 2 Diabetes
GAO Ai-ping， CUI Wei
Department of Endocrinology， First Affiliated Hospital of Xi’an Jiaotong University， Xi’an， Shanxi Province， 710061 China
[Abstract] Objective To study the effect of blood liquid level on the disease activity degree of patients with rheumatoid arthritis with type 2 diabetes. Methods From Norember 2016 to May 2018，The patients of 50 case with rheumatoid arthritis with type 2 diabetes were collected as the research group， while the patients of 50 case with simple type 2 diabetes were selected as the control group， and the blood liquid and blood glucose levels， and the serum inflammatory indexes were compared between the two groups. Results The total cholesterol， triglyceride， low density lipoprotein， fasting blood glucose and glycosylated hemoglobin levels in the control group were obviously lower than those in the research group， and the differences were obvious，the difference was statstically signficant(P<0.05)， and the difference in the high density lipoprotein between the two groups the different was not statstically signficant(P>0.05)， and the CRP and ESR levels in the research group were obviously higher than those in the control group and the difference was obvious，the difference was statstically signficant(P<0.05). Conclusion The blood liquid level and blood glucose level of patients with rheumatoid arthritis with type 2 diabetes are lower than those of patients with simple type 2 diabetes， and it may be related to the high-level inflammatory state of patients.
[Key words] Blood liquid； Rheumatoid arthritis； Type 2 diabetes
类风湿关节炎是一种弥漫性结缔组织疾病，中年女性中多见，常伴有心、肺、神經等外周组织受累。血脂异常指的血清中TG、TC和LDL-C水平高出正常值。研究发现类风湿关节炎合并糖尿病患者的比例明显高于正常人群[1]。那脂、糖代谢紊乱是否与类风湿关节炎患者疾病活动度有关，这是目前研究的热点。因此该文拟收集2016年1月—2018年5月诊断为类风湿关节炎伴2型糖尿病的50例患者，而这些人群的血糖、血脂代谢特点，同时分析上述指标与患者疾病活动度的相关性，现报道如下。
1 资料与方法
1.1 一般资料
收集诊断为类风湿关节炎伴2型糖尿病的患者，定义为研究组，疾病符合美国风湿病学会修订的标准[2]。选择单纯2型糖尿病的患者作为对照组。研究组男26例，女24例，年龄37～64岁，平均年龄(48.28±16.17)岁。对照组男27例，女23例，年龄38～66岁，平均年龄(49.17±15.25)岁。两组性别和年龄比较差异无统计学意义(P>0.05)。, http://www.100md.com(高蔼萍 崔巍)
[关键词] 血脂；类风湿关节炎；2型糖尿病
[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2018)07(a)-0048-02
Effect of Blood Liquid Level on the Disease Activity Degree of Patients with Rheumatoid Arthritis with Type 2 Diabetes
GAO Ai-ping， CUI Wei
Department of Endocrinology， First Affiliated Hospital of Xi’an Jiaotong University， Xi’an， Shanxi Province， 710061 China
[Abstract] Objective To study the effect of blood liquid level on the disease activity degree of patients with rheumatoid arthritis with type 2 diabetes. Methods From Norember 2016 to May 2018，The patients of 50 case with rheumatoid arthritis with type 2 diabetes were collected as the research group， while the patients of 50 case with simple type 2 diabetes were selected as the control group， and the blood liquid and blood glucose levels， and the serum inflammatory indexes were compared between the two groups. Results The total cholesterol， triglyceride， low density lipoprotein， fasting blood glucose and glycosylated hemoglobin levels in the control group were obviously lower than those in the research group， and the differences were obvious，the difference was statstically signficant(P<0.05)， and the difference in the high density lipoprotein between the two groups the different was not statstically signficant(P>0.05)， and the CRP and ESR levels in the research group were obviously higher than those in the control group and the difference was obvious，the difference was statstically signficant(P<0.05). Conclusion The blood liquid level and blood glucose level of patients with rheumatoid arthritis with type 2 diabetes are lower than those of patients with simple type 2 diabetes， and it may be related to the high-level inflammatory state of patients.
[Key words] Blood liquid； Rheumatoid arthritis； Type 2 diabetes
类风湿关节炎是一种弥漫性结缔组织疾病，中年女性中多见，常伴有心、肺、神經等外周组织受累。血脂异常指的血清中TG、TC和LDL-C水平高出正常值。研究发现类风湿关节炎合并糖尿病患者的比例明显高于正常人群[1]。那脂、糖代谢紊乱是否与类风湿关节炎患者疾病活动度有关，这是目前研究的热点。因此该文拟收集2016年1月—2018年5月诊断为类风湿关节炎伴2型糖尿病的50例患者，而这些人群的血糖、血脂代谢特点，同时分析上述指标与患者疾病活动度的相关性，现报道如下。
1 资料与方法
1.1 一般资料
收集诊断为类风湿关节炎伴2型糖尿病的患者，定义为研究组，疾病符合美国风湿病学会修订的标准[2]。选择单纯2型糖尿病的患者作为对照组。研究组男26例，女24例，年龄37～64岁，平均年龄(48.28±16.17)岁。对照组男27例，女23例，年龄38～66岁，平均年龄(49.17±15.25)岁。两组性别和年龄比较差异无统计学意义(P>0.05)。, http://www.100md.com(高蔼萍 崔巍)