前列地尔单药及注射用血栓通联合前列地尔治疗早期糖尿病肾病临床比较(1)
[摘要] 目的 研究比较前列地尔单药及注射用血栓通联合前列地尔在治疗早期糖尿病肾病的临床效果，为临床更好地治疗早期糖尿病肾病提供参考。方法 选该院肾内科就诊的早期糖尿病肾病患者100例。随机分为两组，对照组50例给予前列地尔单药治疗，观察组50例给予注射用血栓通联合前列地尔治疗。比较两组治疗前后在24 h尿蛋白定量、空腹血糖、三酰甘油水平。结果 结果显示，治疗后，两组患者24 h尿蛋白定量、胱抑素C等观察指标都较治疗前显著降低(P<0.05)；治疗后观察组患者的24 h尿蛋白定量、空腹血糖、三酰甘油、胱抑素C等观察指标显著低于对照组(P<0.05)。结论 注射用血栓通联合前列地尔治疗早期糖尿病肾病取得的临床疗效比前列地尔单药治疗早期糖尿病肾病取得的临床效果好。
[关键词] 前列地尔单药；注射用血栓通联合前列地尔；早期糖尿病肾病；临床疗效
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2018)07(b)-0006-02
Clinical Comparison of Single Alprostadil， Injection of Xueshuantong and Alprostadil in Treatment of Early Diabetic Nephropathy
HU Wei， MA Xiao-lu， LONG Yun， CHEN Shuang-qin， LU Shi-long， CHEN Ben-li
Department of Nephrology， Guangxi University of Traditional Chinese Medicine Affiliated Rui Kang Hospital， Nanning， Guangxi， 530011 China
[Abstract] Objective To research and compare the clinical effect of single alprostadil， injection of xueshuantong and alprostadil in treatment of early diabetic nephropathy thus providing reference for the clinical better treatment of early diabetic nephropathy. Methods 100 cases of patients with early diabetic nephropathy diagnosed in our hospital were selected and randomly divided into two groups with 50 cases in each， the control group were treated with single alprostadil， while the observation group used the injection of xueshuantong and alprostadil， and the 24 hour urine protein quantitative， fasting blood glucose and riacylglycerol level were compared before and after treatment between the two groups. Results The results showed that the 24 h urine protein quantitative and cystatin C of the two groups after treatment obviously decreased compared with those before treatment(P<0.05)， after treatment， the 24 hours urine protein quantitation， fasting blood glucose， three glycerol， cystatin C in the observation group were obviously lower than those in the control group(P<0.05). Conclusion The clinical curative effect of injection of xueshuantong and alprostadil in treatment of early diabetic nephropathy is better than that of single alprostadil.
[Key words] Single alprostadil； Injection of xueshuantong； Early diabetic nephropathy； Clinical curative effect
糖尿病是一组以高血糖为特征的代谢性、复杂的慢性、终身性疾病[1]。糖尿病患者因长期存在高血糖，會波及全身各种组织，特别是眼、肾、心脏等器官组织的慢性损害、功能障碍等并发症[2]。糖尿病肾病是糖尿病的并发症之一，最终会导致肾衰竭而威胁着糖尿病患者的健康及生命安全[3]。目前，糖尿病肾病的病因及发病机制尚不明确，与遗传、高血糖造成的代谢异常等有关的因素都会导致该疾病的发生。糖尿病肾病的主要临床表现有慢性高血糖及蛋白尿。临床实践知注射用血栓通、前列地尔都对糖尿病肾病有一定的治疗效果，该研究的主要内容为前列地尔单药及注射用血栓通联合前列地尔治疗早期糖尿病肾病临床效果的比较。现报道如下。, 百拇医药(胡维 马晓露 龙韵 陈双琴 陆世龙 陈本丽)
[关键词] 前列地尔单药；注射用血栓通联合前列地尔；早期糖尿病肾病；临床疗效
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2018)07(b)-0006-02
Clinical Comparison of Single Alprostadil， Injection of Xueshuantong and Alprostadil in Treatment of Early Diabetic Nephropathy
HU Wei， MA Xiao-lu， LONG Yun， CHEN Shuang-qin， LU Shi-long， CHEN Ben-li
Department of Nephrology， Guangxi University of Traditional Chinese Medicine Affiliated Rui Kang Hospital， Nanning， Guangxi， 530011 China
[Abstract] Objective To research and compare the clinical effect of single alprostadil， injection of xueshuantong and alprostadil in treatment of early diabetic nephropathy thus providing reference for the clinical better treatment of early diabetic nephropathy. Methods 100 cases of patients with early diabetic nephropathy diagnosed in our hospital were selected and randomly divided into two groups with 50 cases in each， the control group were treated with single alprostadil， while the observation group used the injection of xueshuantong and alprostadil， and the 24 hour urine protein quantitative， fasting blood glucose and riacylglycerol level were compared before and after treatment between the two groups. Results The results showed that the 24 h urine protein quantitative and cystatin C of the two groups after treatment obviously decreased compared with those before treatment(P<0.05)， after treatment， the 24 hours urine protein quantitation， fasting blood glucose， three glycerol， cystatin C in the observation group were obviously lower than those in the control group(P<0.05). Conclusion The clinical curative effect of injection of xueshuantong and alprostadil in treatment of early diabetic nephropathy is better than that of single alprostadil.
[Key words] Single alprostadil； Injection of xueshuantong； Early diabetic nephropathy； Clinical curative effect
糖尿病是一组以高血糖为特征的代谢性、复杂的慢性、终身性疾病[1]。糖尿病患者因长期存在高血糖，會波及全身各种组织，特别是眼、肾、心脏等器官组织的慢性损害、功能障碍等并发症[2]。糖尿病肾病是糖尿病的并发症之一，最终会导致肾衰竭而威胁着糖尿病患者的健康及生命安全[3]。目前，糖尿病肾病的病因及发病机制尚不明确，与遗传、高血糖造成的代谢异常等有关的因素都会导致该疾病的发生。糖尿病肾病的主要临床表现有慢性高血糖及蛋白尿。临床实践知注射用血栓通、前列地尔都对糖尿病肾病有一定的治疗效果，该研究的主要内容为前列地尔单药及注射用血栓通联合前列地尔治疗早期糖尿病肾病临床效果的比较。现报道如下。, 百拇医药(胡维 马晓露 龙韵 陈双琴 陆世龙 陈本丽)