六味地黄丸治疗糖尿病肾阴虚证的临床分析(1)
[摘要] 目的 分析六味地黄丸治疗糖尿病肾阴虚证的临床效果。 方法 将2017年6月—2018年10月这一时段内在该院治疗的糖尿病肾阴虚证96例纳入研究，按照住院号单双数，将之分为两组，每组48例，对照组给予阿卡波糖治疗，在此基础上，观察组加服六味地黄丸。 结果 观察组的治疗总有效率为95.83%，显著高于对照组的79.17%，两组数据差异有统计学意义(P<0.05);治疗后，观察组尿白蛋白排泄量显著低于对照组，两组数据差异有统计学意义(P<0.05)。结论 六味地黄丸治疗糖尿病肾阴虚证，疗效显著，值得采纳应用。
[关键词] 六味地黄丸;治疗;糖尿病;肾阴虚证
[中图分类号] R9 [文献标识码] A [文章编号] 1672-4062(2019)03(b)-0093-02
[Abstract] Objective To analyze the clinical effect of Liuwei Dihuang Pill in the treatment of diabetic kidney yin deficiency syndrome. Methods 96 cases of diabetic kidney yin deficiency syndrome treated in our hospital from June 2017 to October 2018 were included in the study. According to the hospital number and double number， they were divided into two groups， 48 cases in each group. On the basis of this， the observation group was given Liuwei Dihuang Pills. Results The total effective rate of the observation group was 95.83%， which was significantly higher than that of the control group (79.17%). The difference between the two groups was significant， which was statistically significant(P<0.05). After treatment， the urinary albumin excretion in the observation group was significantly lower than that in the observation group. In the control group， the data of the two groups were significantly different， which was statistically significant(P<0.05). Conclusion Liuwei Dihuang Pill is effective in treating diabetic yin deficiency syndrome and it is worthy of adoption.
[Key words] Liuwei Dihuang Pill; Treatment; Diabetes; Kidney yin deficiency syndrome
糖尿病是一種临床常见的代谢性疾病，其基本特征为高血糖，根据病症特点，可分为Ⅰ型糖尿病和2型糖尿病这两种症型，二者患者比例为1：9[1-2]。作为一种慢性进展性疾病，长期血糖偏高的状态会使得机体代谢紊乱，导致肾脏发生病理性变化，致使气阴两虚、阴虚燥热，长此以往形成淤血，精气外泄，形成糖尿病肾阴虚证[3-4]。按照中医辨证治疗理论，治疗糖尿病肾阴虚证，宜滋阴补肾，可采用六味地黄丸。该次试验选取2017年6月—2018年10月该院的糖尿病肾阳虚证96例进行研究，在糖尿病肾阴虚证治疗中应用了六味地黄丸，反响甚好，现将试验结果作如下报道。
1 资料与方法
1.1 一般资料
将在该院治疗的糖尿病肾阴虚证96例纳入研究，按照住院号单双数，将之分为两组，每组48例。对患者基本资料进行统计分析，具体如下：①对照组。男女比例为28：20，最小、最大年龄分别为45岁、75岁，平均年龄(58.92±3.17)岁;最低、最高病程分别为1年、15年，病程平均为(8.20±2.34)年;②观察组。男女比例为27：21，最小、最大年龄分别为43岁、75岁，平均年龄(59.07±3.26)岁;最低、最高病程分别为2年、15年，病程平均为(8.55±2.42)年。从性别及年龄分布、病程等基本资料上看，对照组和观察组差异无统计学意义(P>0.05)，可进行对比研究。
1.2 纳入及排除标准
(1)纳入标准：①符合《中医内科学》中关于肾阴亏虚证的诊断标准，以尿频、尿多、口干舌燥、腰膝酸软、头晕目眩为主要证见，舌红、脉沉细数;②此次试验在医院所属医学道德伦理委员会监理下展开，将试验内容告知患者后，患者签署知情同意书后，纳入此次研究。
(2)排除标准：①合并有严重心、肝、肾器质病变者;②Ⅰ型糖尿病患者。
1.3 治疗方法
对照组给予阿卡波糖(国药准字H19990205)治疗，用餐前即刻吞服，3次/d，初始剂量为50 mg/次，随后可根据患者的耐受性，将每次剂量增加至0.1 g。, http://www.100md.com(亓铸刚)
[关键词] 六味地黄丸;治疗;糖尿病;肾阴虚证
[中图分类号] R9 [文献标识码] A [文章编号] 1672-4062(2019)03(b)-0093-02
[Abstract] Objective To analyze the clinical effect of Liuwei Dihuang Pill in the treatment of diabetic kidney yin deficiency syndrome. Methods 96 cases of diabetic kidney yin deficiency syndrome treated in our hospital from June 2017 to October 2018 were included in the study. According to the hospital number and double number， they were divided into two groups， 48 cases in each group. On the basis of this， the observation group was given Liuwei Dihuang Pills. Results The total effective rate of the observation group was 95.83%， which was significantly higher than that of the control group (79.17%). The difference between the two groups was significant， which was statistically significant(P<0.05). After treatment， the urinary albumin excretion in the observation group was significantly lower than that in the observation group. In the control group， the data of the two groups were significantly different， which was statistically significant(P<0.05). Conclusion Liuwei Dihuang Pill is effective in treating diabetic yin deficiency syndrome and it is worthy of adoption.
[Key words] Liuwei Dihuang Pill; Treatment; Diabetes; Kidney yin deficiency syndrome
糖尿病是一種临床常见的代谢性疾病，其基本特征为高血糖，根据病症特点，可分为Ⅰ型糖尿病和2型糖尿病这两种症型，二者患者比例为1：9[1-2]。作为一种慢性进展性疾病，长期血糖偏高的状态会使得机体代谢紊乱，导致肾脏发生病理性变化，致使气阴两虚、阴虚燥热，长此以往形成淤血，精气外泄，形成糖尿病肾阴虚证[3-4]。按照中医辨证治疗理论，治疗糖尿病肾阴虚证，宜滋阴补肾，可采用六味地黄丸。该次试验选取2017年6月—2018年10月该院的糖尿病肾阳虚证96例进行研究，在糖尿病肾阴虚证治疗中应用了六味地黄丸，反响甚好，现将试验结果作如下报道。
1 资料与方法
1.1 一般资料
将在该院治疗的糖尿病肾阴虚证96例纳入研究，按照住院号单双数，将之分为两组，每组48例。对患者基本资料进行统计分析，具体如下：①对照组。男女比例为28：20，最小、最大年龄分别为45岁、75岁，平均年龄(58.92±3.17)岁;最低、最高病程分别为1年、15年，病程平均为(8.20±2.34)年;②观察组。男女比例为27：21，最小、最大年龄分别为43岁、75岁，平均年龄(59.07±3.26)岁;最低、最高病程分别为2年、15年，病程平均为(8.55±2.42)年。从性别及年龄分布、病程等基本资料上看，对照组和观察组差异无统计学意义(P>0.05)，可进行对比研究。
1.2 纳入及排除标准
(1)纳入标准：①符合《中医内科学》中关于肾阴亏虚证的诊断标准，以尿频、尿多、口干舌燥、腰膝酸软、头晕目眩为主要证见，舌红、脉沉细数;②此次试验在医院所属医学道德伦理委员会监理下展开，将试验内容告知患者后，患者签署知情同意书后，纳入此次研究。
(2)排除标准：①合并有严重心、肝、肾器质病变者;②Ⅰ型糖尿病患者。
1.3 治疗方法
对照组给予阿卡波糖(国药准字H19990205)治疗，用餐前即刻吞服，3次/d，初始剂量为50 mg/次，随后可根据患者的耐受性，将每次剂量增加至0.1 g。, http://www.100md.com(亓铸刚)