油酰乙醇胺对糖尿病大鼠脑内炎性因子及神经相关因子表达的影响(3)
綜上所述，结果显示OEA具有抑制糖尿病后海马内炎症因子分泌，调节神经可塑性的作用，而这些作用与糖尿病脑病的进程和发展息息相关，因此推测OEA是一种具有减轻糖尿病引起的认知功能缺陷的潜力的神经保护制剂，可用于糖尿病脑病药物的研究。
[参考文献]
[1] Bhutada P，Mundhada Y，Bansod K，et al.Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes[J].Behavioural brain research，2011，220(1)：30-41.
[2] Aulston BD，Schapansky J，Huang Y，et al.Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes-induced encephalopathy[J].Experimental neurology，2018(303)：29-37.
[3] Pugazhenthi S，Qin L，Reddy PH.Common neurodegenerative pathways in obesity， diabetes， and Alzheimer's disease[J].Biochimica et biophysica acta，2017，1863(5)：1037-1045.
[4] D'Orio B，Fracassi A，Ceru MP，et al.PPARalpha in Alzheimers disease[J].Curr.Alzheimer Res，2018(15)：345-354.
[5] Ren T，Yang WS，Lin Y，et al.A novel PPARalpha/gamma agonist， propane-2-sulfonic acid octadec-9-enyl-amide， ameliorates insulin resistance and gluconeogenesis in vivo and vitro[J].European journal of pharmacology，2018(826)：1-8.
[6] Zhou H，Yang WS，Li Y，et al.Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-kappaB and ERK1/2 signaling pathways in mice with acute ischemic stroke[J].Naunyn-Schmiedeberg's archives of pharmacology，2017，390(1)：77-84.
(收稿日期：2019-10-12), http://www.100md.com(刘金凤 许东伟 王幼娟 杨武双)
[参考文献]
[1] Bhutada P，Mundhada Y，Bansod K，et al.Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes[J].Behavioural brain research，2011，220(1)：30-41.
[2] Aulston BD，Schapansky J，Huang Y，et al.Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes-induced encephalopathy[J].Experimental neurology，2018(303)：29-37.
[3] Pugazhenthi S，Qin L，Reddy PH.Common neurodegenerative pathways in obesity， diabetes， and Alzheimer's disease[J].Biochimica et biophysica acta，2017，1863(5)：1037-1045.
[4] D'Orio B，Fracassi A，Ceru MP，et al.PPARalpha in Alzheimers disease[J].Curr.Alzheimer Res，2018(15)：345-354.
[5] Ren T，Yang WS，Lin Y，et al.A novel PPARalpha/gamma agonist， propane-2-sulfonic acid octadec-9-enyl-amide， ameliorates insulin resistance and gluconeogenesis in vivo and vitro[J].European journal of pharmacology，2018(826)：1-8.
[6] Zhou H，Yang WS，Li Y，et al.Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-kappaB and ERK1/2 signaling pathways in mice with acute ischemic stroke[J].Naunyn-Schmiedeberg's archives of pharmacology，2017，390(1)：77-84.
(收稿日期：2019-10-12), http://www.100md.com(刘金凤 许东伟 王幼娟 杨武双)