参芪地黄汤与穴位贴敷联合治疗早期糖尿病肾病的疗效研究(1)
[摘要] 目的 探讨参芪地黄汤与穴位贴敷联合治疗早期糖尿病肾病的疗效。方法 选择2018年8月—2019年8月该院收治的80例早期糖尿病肾病患者作为研究对象，以随机数表法将其随机分为两组，其中对照组与研究组，各40例。对照组患者采取基础治疗，研究组在此基础上应用中药参芪地黄汤与中药外敷贴穴位治疗。评价并对比两组临床疗效、治疗前后肾功能指标[尿素氮(BUN)、胱抑素C(Cysc)、血肌酐(SCr)] 的变化，以及两组不良反应情况。结果 研究组治疗的总有效率95.00%高于对照组75.00%(P<0.05);治疗后研究组BUN、Cysc与SCr水平均低于对照组(P<0.05);研究组与对照组治疗期间均未见明显的不良反应。结论 参芪地黄汤与穴位贴敷联合治疗早期糖尿病肾病疗效可靠，值得临床推广。
[关键词] 参芪地黄汤;穴位贴敷;早期糖尿病肾病;疗效
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)06(b)-0189-03
[Abstract] Objective To explore the effect of Shenqi Dihuang Decoction combined with acupoint application on early diabetic nephropathy. Methods Eighty patients with early diabetic nephropathy admitted to our hospital from August 2018 to August 2019 were selected as the research object， and they were randomly divided into two groups by random number table method， including 40 cases in the control group and the research group. The patients in the control group were treated with basic treatment. On the basis of this， the research group was treated with Shenqi Dihuang Decoction and acupoint application. Evaluate and compare the clinical efficacy， changes in renal function indexes [urea nitrogen (BUN)， cystatin C (Cysc)， blood creatinine (SCr)] before and after treatment， as well as adverse reactions in the two groups. Results The total effective rate of treatment in the study group was 95.00% higher than that in the control group (75.00% (P<0.05); after treatment， the levels of BUN， Cysc and SCr in the study group were lower than that in the control group (P<0.05); No obvious adverse reactions were observed during this period in the study group and control group. Conclusion The combination of Shenqi Dihuang Decoction and acupoint application in the treatment of early diabetic nephropathy is reliable and worthy of clinical promotion.
[Key words] Shenqi Dihuang Decoction; Acupoint Application; Early Diabetic Nephropathy; Efficacy
糖尿病腎病是糖尿病患者的严重并发症，临床表现为水肿、蛋白尿等，若未及时采取有效的治疗措施，随着肾脏的进一步损伤可诱发尿毒症，给患者的健康与生命安全带来严重的影响[1]。目前，临床针对早期糖尿病肾病主要予以西药降糖治疗，以期改善临床症状，延缓疾病进展。然而，部分研究发现单纯西医基础治疗对于早期糖尿病肾病的治疗效果仍有所欠缺[2]。中医认为，早期糖尿病肾病属于“下消”“消渴”的范畴，该病以燥热为标，阴虚为本，主要与消渴症迁延难愈，气阴两虚，肾气不足，失于固摄，致使水浴精微下注有关，故应取滋肾补气之法，并辅以化瘀、血活、健脾进行治疗[3]。2018年8月—2019年8月该院对40例早期糖尿病肾病患者应用了参芪地黄汤与穴位贴敷联合治疗，临床收效显著，患者肾功能指标得到了显著改善，现报道如下。
1 资料与方法
1.1 一般资料
选择该院收治的80例早期糖尿病肾病患者作为研究对象，以随机数表法将其随机分为两组，其中对照组与研究组，各40例。纳入标准：西医诊断符合1999年世界卫生组织对糖尿病肾病的相关标准，且持续3次检测24 h尿蛋白中有2次的结果在30～300 mg/24 h;中医诊断符合《糖尿病肾病中医防治指南》中的诊断标准，且辨证为瘀血内阻、气阴亏虚型;该次研究方案已告知患者知情，并已签署“知情同意书”。排除标准：原发性肾病;合并严重脏器功能障碍;免疫系统与血液系统疾病;恶性肿瘤;近期存在糖尿病急性并发症;长期酗酒;活动性炎症或严重感染;哺乳期与妊娠期女性;有精神疾病史。对照组：男性25例，女性15例;年龄 43～70岁，平均年龄(56.6±4.5)岁;病程1～12年，平均(4.3±1.2)年。研究组：男性24例，女性16例;年龄 43～72岁，平均年龄(56.5±4.3)岁;病程1～12年，平均(4.2±1.3)年。在性别、年龄与病程对比中，研究组与对照组间差异无统计学意义(P>0.05)。该文研究内容经医院伦理委员会审核与批准。, http://www.100md.com(魏春华)
[关键词] 参芪地黄汤;穴位贴敷;早期糖尿病肾病;疗效
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)06(b)-0189-03
[Abstract] Objective To explore the effect of Shenqi Dihuang Decoction combined with acupoint application on early diabetic nephropathy. Methods Eighty patients with early diabetic nephropathy admitted to our hospital from August 2018 to August 2019 were selected as the research object， and they were randomly divided into two groups by random number table method， including 40 cases in the control group and the research group. The patients in the control group were treated with basic treatment. On the basis of this， the research group was treated with Shenqi Dihuang Decoction and acupoint application. Evaluate and compare the clinical efficacy， changes in renal function indexes [urea nitrogen (BUN)， cystatin C (Cysc)， blood creatinine (SCr)] before and after treatment， as well as adverse reactions in the two groups. Results The total effective rate of treatment in the study group was 95.00% higher than that in the control group (75.00% (P<0.05); after treatment， the levels of BUN， Cysc and SCr in the study group were lower than that in the control group (P<0.05); No obvious adverse reactions were observed during this period in the study group and control group. Conclusion The combination of Shenqi Dihuang Decoction and acupoint application in the treatment of early diabetic nephropathy is reliable and worthy of clinical promotion.
[Key words] Shenqi Dihuang Decoction; Acupoint Application; Early Diabetic Nephropathy; Efficacy
糖尿病腎病是糖尿病患者的严重并发症，临床表现为水肿、蛋白尿等，若未及时采取有效的治疗措施，随着肾脏的进一步损伤可诱发尿毒症，给患者的健康与生命安全带来严重的影响[1]。目前，临床针对早期糖尿病肾病主要予以西药降糖治疗，以期改善临床症状，延缓疾病进展。然而，部分研究发现单纯西医基础治疗对于早期糖尿病肾病的治疗效果仍有所欠缺[2]。中医认为，早期糖尿病肾病属于“下消”“消渴”的范畴，该病以燥热为标，阴虚为本，主要与消渴症迁延难愈，气阴两虚，肾气不足，失于固摄，致使水浴精微下注有关，故应取滋肾补气之法，并辅以化瘀、血活、健脾进行治疗[3]。2018年8月—2019年8月该院对40例早期糖尿病肾病患者应用了参芪地黄汤与穴位贴敷联合治疗，临床收效显著，患者肾功能指标得到了显著改善，现报道如下。
1 资料与方法
1.1 一般资料
选择该院收治的80例早期糖尿病肾病患者作为研究对象，以随机数表法将其随机分为两组，其中对照组与研究组，各40例。纳入标准：西医诊断符合1999年世界卫生组织对糖尿病肾病的相关标准，且持续3次检测24 h尿蛋白中有2次的结果在30～300 mg/24 h;中医诊断符合《糖尿病肾病中医防治指南》中的诊断标准，且辨证为瘀血内阻、气阴亏虚型;该次研究方案已告知患者知情，并已签署“知情同意书”。排除标准：原发性肾病;合并严重脏器功能障碍;免疫系统与血液系统疾病;恶性肿瘤;近期存在糖尿病急性并发症;长期酗酒;活动性炎症或严重感染;哺乳期与妊娠期女性;有精神疾病史。对照组：男性25例，女性15例;年龄 43～70岁，平均年龄(56.6±4.5)岁;病程1～12年，平均(4.3±1.2)年。研究组：男性24例，女性16例;年龄 43～72岁，平均年龄(56.5±4.3)岁;病程1～12年，平均(4.2±1.3)年。在性别、年龄与病程对比中，研究组与对照组间差异无统计学意义(P>0.05)。该文研究内容经医院伦理委员会审核与批准。, http://www.100md.com(魏春华)