二甲双胍用于妊娠合并糖尿病治疗对母婴结局的影响研究(1)
DOI：10.16658/j.cnki.1672-4062.2020.20.100
[摘要] 目的 探讨二甲双胍应用于妊娠糖尿病患者中对母婴结局的影响。方法 选取该院2017年1月—2019年1月收治的妊娠糖尿病患者68例，将患者随机分为两组，对照组以常规治疗配合胰岛素治疗，研究组以常规治疗配合二甲双胍治疗，对比两组患者、围生儿并发症发生情况。结果 并发症发生情况中，对照组8例患者产前检查为子痫前期，发生率为23.53%，12例患者行剖腹产，占比35.29%。观察组患者1例患者产前检查为子痫前期，发生率为2.94%，2例患者行剖腹产，占比5.88%。两项数据指标差异有统计学意义(P<0.05);围生儿并发症发生情况中，对照组为35.29%，研究组为11.76%，数据差异有统计学意义(χ2=5.231，P<0.05)。 结论 妊娠糖尿病患者采用二甲双胍治疗，能够降低产妇及围生儿并发症发生率，在母婴结局上较好。
[关键词] 二甲双胍;妊娠糖尿病;母婴结局
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)10(b)-0100-03
Study on the Effect of Metformin in the Treatment of Pregnancy Complicated with Diabetes on Maternal and Infant Outcomes
LIU Li-ping
Department of Obstetrics and Gynecology， Affiliated Hospital of Huizhou Vocational and Technical College， Huizhou， Guangdong Province， 516000 China
[Abstract] Objective To explore the effect of dimethyl double arc used in patients with gestational diabetes on maternal and infant outcomes. Methods A total of 68 patients with gestational diabetes who were admitted to the hospital from January 2017 to January 2019 were selected and randomly divided into two groups. The control group received conventional therapy combined with insulin therapy， and the study group received conventional therapy combined with dimethyl double arc therapy. The complications of the two groups of patients and perinatal infants were compared. Results In the incidence of maternal complications， 8 patients in the control group had preeclampsia in pre-eclampsia， the incidence was 23.53%， and 12 patients underwent cesarean section， accounting for 35.29%. In the observation group， 1 patient had pre-eclampsia during pre-eclampsia， the incidence was 2.94%， and 2 patients underwent cesarean section， accounting for 5.88%. There was a statistically significant difference between the two data indicators(P<0.05); in the incidence of perinatal complications， 35.29% in the control group and 11.76% in the study group， the data difference was statistically significant(χ2=5.231， P<0.05). Conclusion The use of dimethyl double arc therapy in patients with gestational diabetes can reduce the incidence of maternal and perinatal complications， and has better maternal and infant outcomes.
[Key words] Dimethyl double arc; Gestational diabetes; Maternal and infant outcome
妊娠糖尿病是由于妊娠期孕婦机体糖代谢异常引发的疾病，与糖尿病合并妊娠不同，是患者进入妊娠期后才产生的疾病。妊娠糖尿病对于产妇及胎儿皆具有不良影响，可能造成产妇流产、感染、引发胎儿出生缺陷或造成围生儿死亡等不良妊娠结局。且由于妊娠期糖尿病在早期无典型特征，所以常存在产妇不重视，未及时加以干预治疗的情况，造成病情的加重，对产妇及围生儿健康水平产生更大的影响[1]。在妊娠期糖尿病患者的治疗中，还需要提高及时性，给予对症治疗。临床上治疗妊娠糖尿病，以控制患者血糖为主要目的，因此不仅需要合理干预产妇饮食中糖分摄入，指导患者适当运动增强机体糖代谢能力，还需要配合药物治疗起到降糖目的，保持产妇血糖平衡，减少血糖波动造成对产妇及围生儿的影响[2]。临床上常用于治疗妊娠糖尿病的药物包括有胰岛素、二甲双胍等降血糖药物，而不同药物在疗效上不同，为确定不同药物治疗效果及药物治疗下对母婴结局的影响，以该院2017年1月—2019年1月收治的68例妊娠糖尿病患者为研究对象展开具体分析研究，现报道如下。, 百拇医药(刘丽萍)
[摘要] 目的 探讨二甲双胍应用于妊娠糖尿病患者中对母婴结局的影响。方法 选取该院2017年1月—2019年1月收治的妊娠糖尿病患者68例，将患者随机分为两组，对照组以常规治疗配合胰岛素治疗，研究组以常规治疗配合二甲双胍治疗，对比两组患者、围生儿并发症发生情况。结果 并发症发生情况中，对照组8例患者产前检查为子痫前期，发生率为23.53%，12例患者行剖腹产，占比35.29%。观察组患者1例患者产前检查为子痫前期，发生率为2.94%，2例患者行剖腹产，占比5.88%。两项数据指标差异有统计学意义(P<0.05);围生儿并发症发生情况中，对照组为35.29%，研究组为11.76%，数据差异有统计学意义(χ2=5.231，P<0.05)。 结论 妊娠糖尿病患者采用二甲双胍治疗，能够降低产妇及围生儿并发症发生率，在母婴结局上较好。
[关键词] 二甲双胍;妊娠糖尿病;母婴结局
[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062(2020)10(b)-0100-03
Study on the Effect of Metformin in the Treatment of Pregnancy Complicated with Diabetes on Maternal and Infant Outcomes
LIU Li-ping
Department of Obstetrics and Gynecology， Affiliated Hospital of Huizhou Vocational and Technical College， Huizhou， Guangdong Province， 516000 China
[Abstract] Objective To explore the effect of dimethyl double arc used in patients with gestational diabetes on maternal and infant outcomes. Methods A total of 68 patients with gestational diabetes who were admitted to the hospital from January 2017 to January 2019 were selected and randomly divided into two groups. The control group received conventional therapy combined with insulin therapy， and the study group received conventional therapy combined with dimethyl double arc therapy. The complications of the two groups of patients and perinatal infants were compared. Results In the incidence of maternal complications， 8 patients in the control group had preeclampsia in pre-eclampsia， the incidence was 23.53%， and 12 patients underwent cesarean section， accounting for 35.29%. In the observation group， 1 patient had pre-eclampsia during pre-eclampsia， the incidence was 2.94%， and 2 patients underwent cesarean section， accounting for 5.88%. There was a statistically significant difference between the two data indicators(P<0.05); in the incidence of perinatal complications， 35.29% in the control group and 11.76% in the study group， the data difference was statistically significant(χ2=5.231， P<0.05). Conclusion The use of dimethyl double arc therapy in patients with gestational diabetes can reduce the incidence of maternal and perinatal complications， and has better maternal and infant outcomes.
[Key words] Dimethyl double arc; Gestational diabetes; Maternal and infant outcome
妊娠糖尿病是由于妊娠期孕婦机体糖代谢异常引发的疾病，与糖尿病合并妊娠不同，是患者进入妊娠期后才产生的疾病。妊娠糖尿病对于产妇及胎儿皆具有不良影响，可能造成产妇流产、感染、引发胎儿出生缺陷或造成围生儿死亡等不良妊娠结局。且由于妊娠期糖尿病在早期无典型特征，所以常存在产妇不重视，未及时加以干预治疗的情况，造成病情的加重，对产妇及围生儿健康水平产生更大的影响[1]。在妊娠期糖尿病患者的治疗中，还需要提高及时性，给予对症治疗。临床上治疗妊娠糖尿病，以控制患者血糖为主要目的，因此不仅需要合理干预产妇饮食中糖分摄入，指导患者适当运动增强机体糖代谢能力，还需要配合药物治疗起到降糖目的，保持产妇血糖平衡，减少血糖波动造成对产妇及围生儿的影响[2]。临床上常用于治疗妊娠糖尿病的药物包括有胰岛素、二甲双胍等降血糖药物，而不同药物在疗效上不同，为确定不同药物治疗效果及药物治疗下对母婴结局的影响，以该院2017年1月—2019年1月收治的68例妊娠糖尿病患者为研究对象展开具体分析研究，现报道如下。, 百拇医药(刘丽萍)