[摘要] 目的 应用二维斑点追踪纵向应变评价蒽环类药物对乳癌病人左心房功能的影响并探讨其临床意义。方法 选取以蒽环类药物化疗为主的乳癌病人52例，均行6周期化疗，分别于化疗前及化疗第2、4、6周期行二维斑点追踪技术检查，检测左心房整体纵向应变(GLS)、左心房储备期峰值应变(SRs)、左心房通道期峰值應变(SRe)及左心房辅泵期峰值应变(SRa)。以同期30例健康志愿者为正常对照组。结果 乳癌病人化疗第4、6周期的左心房GLS、SRs、SRe及SRa均低于对照组及乳癌病人化疗前、化疗第2周期，化疗第6周期的左心房GLS、SRs、SRe、SRa较第4周期降低，差异有统计学意义(F=21.044～53.702，P<0.05)。结论 应用二维斑点追踪技术评估蒽环类药物对射血分数正常的乳癌病人的左心房功能影响有一定临床价值。

    [关键词] 乳房肿瘤;心房功能，左;超声心动描记术;肌细胞，心脏;细胞凋亡

    [中图分类号] R737.9;R540.5 [文献标志码] A [文章编号] 2096-5532(2020)06-0671-04

    doi：10.11712/jms.2096-5532.2020.56.159 [开放科学(资源服务)标识码(OSID)]

    [网络出版] https：//kns.cnki.net/kcms/detail/37.1517.R.20200720.1401.003.html;

    [ABSTRACT] Objective To investigate the value of two-dimensional speckle tracking and longitudinal strain in evaluating the influence of anthracyclines on left atrial function in breast cancer patients. Methods A total of 52 breast cancer patients who received chemotherapy based on anthracyclines were enrolled and were all treated for 6 chemotherapy cycles. Before chemotherapy and at cycles 2 ......