【摘要】腰椎背根神经节的小细胞中有多种神经肽，包括P物质(SubstanceP，SP)和降钙素基因相关肽(calcitoningene-relatedpeptide，CGRP)等。研究发现在腰椎髓核、纤维环、腰椎小关节及关节囊等均有SP和CGRP阳性神经纤维分布，且SP和CGRP不仅有信息的传递、调控以及伤害感受性感觉的神经递质和调节功能，还具有血管活性作用，可发生神经源性神经肽介导的炎症损伤，在慢性腰背痛中起重要作用。调控中枢神经系统的多种神经肽的相互作用和其调控因素均不清楚，尚有待进一步在受体和基因表达水平进行深入研究。有效的SP和CGRP受体拮抗剂应用于慢性腰背痛治疗有待于进一步研究。

    【关键词】P物质(SP) 降钙素基因相关肽(CGRP)背根神经节(DRG)慢性腰背痛

    【Abstract】 There are many small neurons that contain neuropeptides including SP and CGRP in dorsal root ganglions. It’s reported that the lumbar anulus fibrosus, lumbar nucleus pulpouss, lumbar facet joints and joint capsules that contain SP-IR and CGRP-IR peptide-containing neurons, and SP、CGRP are important reasons for chronic low-back pain, have a more significant role in transmitting and regulating informations of sensory neurotransmitter of nociception ,activing blood vessels,and to result in inflammatory impairment mediated by neuropeptides. It’s unknowed that how neuropeptides interact and what regulating factors are,so advanced researchs are necessary. TO cure pains caused by chronic low-back pain by effective SP、CGRP-receptor antagonist ,more workes shoud to do. ......