绝经后子宫内膜出血的临床病理分析(1)
【摘 要】目的:研究绝经后子宫出血的病因,诊刮子宫内膜的病检及意义。方法:我院85例绝经后子宫出血的患者行诊刮术后子宫内膜组织送病检,标本以中性甲醛液固定,常规行石蜡包埋,HE染色后光镜下划分病理类型,作出结果统计。结果:恶性肿瘤8例,腺癌为主;良性病变42例,单纯性增生及子宫内膜炎为主;非器质性病变35例,萎缩性子宫内膜占多数。结论:患者一旦出现绝经后子宫出血,需及时诊刮作病理检查,特别是老年妇女并绝经时间长者,在常规妇检后,须对可疑者行分段刮宫取子宫内膜作病理诊断。
【关键词】绝经后子宫出血;子宫内膜;病理诊断;恶性肿瘤;良性病变;非器质性病变
Clinicopathological analysis of postmenopausal endometrial bleeding
Wang Wei Yang Guifang
1.Zhongnan Hospital of Wuhan Univercity ; Wuhan Iron and Steel General Hospital Hubei 430080
2. pathology department Zhongnan Hospital of Wuhan Univercity Hubei 430080
[Abstract] objective: to study the cause of postmenopausal uterine bleeding, clinical shave of endometrial disease and the significance. Methods: our hospital 85 cases of postmenopausal uterine bleeding of patients with clinical postoperative endometrial tissue disease screening, specimens with neutral formalin fixed, conventional paraffin embedding, after HE staining under pathological type, make the result statistics. Results: 8 cases of malignant tumor, adenocarcinoma is given priority to; 42 cases of benign pathological changes, simple hyperplasia and endometritis primarily; Nonorganic lesions in 35 cases, atrophic endometrium accounted for the majority. Conclusion: once the patients with postmenopausal uterine bleeding, should be timely diagnosis for pathologic examination, elderly people, especially older women and postmenopausal time in conventional woman after checking, please kindly for suspicious line segment curettage endometrial pathologic diagnosis.
[Key words] postmenopausal uterine bleeding; Endometrium; Pathological diagnosis; Malignant tumor; Benign lesions; Nonorganic lesions
绝经后子宫出血(PMUB)是指绝经一年后,患者出现的子宫出血的症状,有研究指出PMUB的发生率约为10%。绝经后阴道出血是妇女绝经后就诊的常见疾病,占老年妇科疾病的80%以上[ 1 ]。绝经后子宫出血的患者诊刮后获取子宫内膜组织行病理检查,可有效的得出诊断并及时治疗[2]。本文通过85例绝经后子宫出血诊刮后的病理诊断,与临床分析相结合,以总结引起子宫出血的规律性原因,并探讨绝经后子宫内膜出血病理诊断的意义。
l 对象和方法
1.1 临床资料:选取我院2011年-2013年妇产科85例绝经后出血患者,年龄最小43岁,最大78岁,平均56.35岁,多数于50~60岁之间。绝经时间约1~32年,出血时间约3~30天,有的反复不规则出血2~6月。患者诊刮前均行腹部B超并排除全身性出血疾病,除外阴道,宫颈,尿道引起的出血,诊刮后病检为最终诊断。
1.2 研究方法:诊刮术后全部子宫内膜组织作病理检查,以中性甲醛液固定,,常规行石蜡包埋,HE染色后光镜下划分子宫内膜病理类型,找寻子宫出血与绝经年龄及病理类型的关系,予Microsoft Excel数据库进行统计分析。
2 结果
2.1 病理诊断结果
恶性肿瘤8例.占9.41%,低于相关资料报道[3]。平均发病年龄65.2岁。良性病变42例,占49.41%,平均发病年龄57.8岁。非器质性病变35例,占41.18%,平均发病年龄48.1岁.发病年龄都在绝经后1~5年内(表1)。![](/images/paper/1672-6383B/201302/20130208-1-l.jpg)
2.2 绝经年限与恶性肿瘤的关系
在绝经后20年内63例患者中,恶性肿瘤发生4例,占6.35%,其中内膜癌3例,内膜间质肉瘤l例。22例患者绝经时间超过20年,其中恶性肿瘤4例,占18.18%,内膜癌3例,间质肉瘤1例。, 百拇医药(王薇 杨桂芳)
【关键词】绝经后子宫出血;子宫内膜;病理诊断;恶性肿瘤;良性病变;非器质性病变
Clinicopathological analysis of postmenopausal endometrial bleeding
Wang Wei Yang Guifang
1.Zhongnan Hospital of Wuhan Univercity ; Wuhan Iron and Steel General Hospital Hubei 430080
2. pathology department Zhongnan Hospital of Wuhan Univercity Hubei 430080
[Abstract] objective: to study the cause of postmenopausal uterine bleeding, clinical shave of endometrial disease and the significance. Methods: our hospital 85 cases of postmenopausal uterine bleeding of patients with clinical postoperative endometrial tissue disease screening, specimens with neutral formalin fixed, conventional paraffin embedding, after HE staining under pathological type, make the result statistics. Results: 8 cases of malignant tumor, adenocarcinoma is given priority to; 42 cases of benign pathological changes, simple hyperplasia and endometritis primarily; Nonorganic lesions in 35 cases, atrophic endometrium accounted for the majority. Conclusion: once the patients with postmenopausal uterine bleeding, should be timely diagnosis for pathologic examination, elderly people, especially older women and postmenopausal time in conventional woman after checking, please kindly for suspicious line segment curettage endometrial pathologic diagnosis.
[Key words] postmenopausal uterine bleeding; Endometrium; Pathological diagnosis; Malignant tumor; Benign lesions; Nonorganic lesions
绝经后子宫出血(PMUB)是指绝经一年后,患者出现的子宫出血的症状,有研究指出PMUB的发生率约为10%。绝经后阴道出血是妇女绝经后就诊的常见疾病,占老年妇科疾病的80%以上[ 1 ]。绝经后子宫出血的患者诊刮后获取子宫内膜组织行病理检查,可有效的得出诊断并及时治疗[2]。本文通过85例绝经后子宫出血诊刮后的病理诊断,与临床分析相结合,以总结引起子宫出血的规律性原因,并探讨绝经后子宫内膜出血病理诊断的意义。
l 对象和方法
1.1 临床资料:选取我院2011年-2013年妇产科85例绝经后出血患者,年龄最小43岁,最大78岁,平均56.35岁,多数于50~60岁之间。绝经时间约1~32年,出血时间约3~30天,有的反复不规则出血2~6月。患者诊刮前均行腹部B超并排除全身性出血疾病,除外阴道,宫颈,尿道引起的出血,诊刮后病检为最终诊断。
1.2 研究方法:诊刮术后全部子宫内膜组织作病理检查,以中性甲醛液固定,,常规行石蜡包埋,HE染色后光镜下划分子宫内膜病理类型,找寻子宫出血与绝经年龄及病理类型的关系,予Microsoft Excel数据库进行统计分析。
2 结果
2.1 病理诊断结果
恶性肿瘤8例.占9.41%,低于相关资料报道[3]。平均发病年龄65.2岁。良性病变42例,占49.41%,平均发病年龄57.8岁。非器质性病变35例,占41.18%,平均发病年龄48.1岁.发病年龄都在绝经后1~5年内(表1)。
![](/images/paper/1672-6383B/201302/20130208-1-l.jpg)
2.2 绝经年限与恶性肿瘤的关系
在绝经后20年内63例患者中,恶性肿瘤发生4例,占6.35%,其中内膜癌3例,内膜间质肉瘤l例。22例患者绝经时间超过20年,其中恶性肿瘤4例,占18.18%,内膜癌3例,间质肉瘤1例。, 百拇医药(王薇 杨桂芳)