间苯三酚联合中药治疗早期先兆流产的临床探讨(1)
【摘 要】目的：探讨间苯三酚联合中药治疗早期先兆流产的临床效果。方法：将妊娠8～12周的86例先兆流产的孕妇随机分为实验组(45例)和对照组(41例)。实验组给予间苯三酚联合中药及黄体酮治疗，对照组仅给予黄体酮及中药治疗。结果：实验组保胎成功有效率明显高于对照组(91.11% VS 78.04%，P<0.05)。治疗期间未见明显不良反应。结论：早期先兆流产患者出现宫缩时，可首选间苯三酚，间苯三酚联合中药及黄体酮治疗孕8～12周的先兆流产安全有效。
【关键词】间苯三酚；中药；早期先兆流产
Clinical study of the treatment for threatened abortion by phloroglucinol and chinese herb
LI Hongju1 LU Peiling2 JIN guixiang3
1.Rizhao Center for Disease Control and Prevention Shandong Rizhao 276800
2.Rizhao Hospital of Traditional Chinese Medicine 276800 3.Rizhao Ju Xian People’s Hospital 276800
[Abstract]Objective： To study the clinical efficacy of phloroglucinol and chinese herb for threatened abortion. Methods： 86 patients with threatened abortion between 8-12 weeks of gestation were randomly divided into experimental group(45 cases) and control group(41 cases).The experimental group were given phloroglucinol and Chinese herb and progesterone，the control group were given progesterone and Chinese herb.Results： The experimental group had more significantly statistical difference than the control group in the effect of prevent miscarriage(91.11% VS 78.04%，P<0.05).There is no untoward effect during the treatment.Conclusion： If patients with early threatened abortion have contractions， phloroglucinol is the first to be selected.It is safe and effective to treat threatened abortion between 8-12 weeks of gestation by phloroglucinol and chinese herb and progesterone.
[key words]Phloroglucinol；Chinese herb；Early threatened abortion
先兆流产主要表现为停经后出现少量阴道流血，伴下腹痛或腰骶部坠胀痛，疼痛的原因是由于宫腔内血肿，个别子宫敏感性较高等原因，引发子宫收缩，如不及时正确地治疗，则可能发展为难免流产。尽早应用解痉及宫缩抑制剂较为重要，是决定使妊娠是否继续的关键。从2012年2月我们开始使用间苯三酚联合中药及黄体酮治疗早期先兆流产，取得了满意的临床效果。
1 资料与方法
1.1 一般资料 选择2012年2月至2013年8月的住院病例，患者年龄22～36岁，平均年龄(27.62±5.41)岁，妊娠8～12周诊断为先兆流产的孕妇86例，15ng/ml0.05)。
1.2 早期先兆流产的诊断标准 妊娠12周前先出现少量阴道流血，暗红色或血性白带，无妊娠物排出，随后出现阵发性下腹痛或腰背痛。妇科检查宫颈口未开，胎膜未破，子宫大小与停经周数相符[1]。
1.3 治疗方法 实验组：间苯三酚120mg(南京恒生制药有限公司)加入5%葡萄糖500ml静脉点滴，滴速30滴/分，一日一次，症状及体征消失停用。口服中药，方用寿胎丸《医学衷中参参西录》加减：菟丝子12g，桑寄生15g，续断20g，党参10g，白术12g，杜仲10g，黄芪(生)10g，熟地10g，酒萸肉6g，地榆炭10g，一副水煎一日两次服用，连用至少4周。黄体酮20mg肌注，一日一次，每周检测一次血清孕酮水平，当孕酮>40ng/ml，改为口服黄体酮胶丸100mg，一日一次，一周后停用。对照组：用黄体酮及中药，用法同实验组。嘱患者卧床休息，禁止性生活，尽量减少阴道检查。
1.4 观察指标 ①有效：宫缩抑制，腹部不适缓解，阴道流血减少渐停止，胚胎或胎儿正常生长。②无效：妊娠组织排出，妊娠终止。③用药及住院时间。④药物不良反应。, http://www.100md.com(李洪菊 卢培玲 靳桂香)
【关键词】间苯三酚；中药；早期先兆流产
Clinical study of the treatment for threatened abortion by phloroglucinol and chinese herb
LI Hongju1 LU Peiling2 JIN guixiang3
1.Rizhao Center for Disease Control and Prevention Shandong Rizhao 276800
2.Rizhao Hospital of Traditional Chinese Medicine 276800 3.Rizhao Ju Xian People’s Hospital 276800
[Abstract]Objective： To study the clinical efficacy of phloroglucinol and chinese herb for threatened abortion. Methods： 86 patients with threatened abortion between 8-12 weeks of gestation were randomly divided into experimental group(45 cases) and control group(41 cases).The experimental group were given phloroglucinol and Chinese herb and progesterone，the control group were given progesterone and Chinese herb.Results： The experimental group had more significantly statistical difference than the control group in the effect of prevent miscarriage(91.11% VS 78.04%，P<0.05).There is no untoward effect during the treatment.Conclusion： If patients with early threatened abortion have contractions， phloroglucinol is the first to be selected.It is safe and effective to treat threatened abortion between 8-12 weeks of gestation by phloroglucinol and chinese herb and progesterone.
[key words]Phloroglucinol；Chinese herb；Early threatened abortion
先兆流产主要表现为停经后出现少量阴道流血，伴下腹痛或腰骶部坠胀痛，疼痛的原因是由于宫腔内血肿，个别子宫敏感性较高等原因，引发子宫收缩，如不及时正确地治疗，则可能发展为难免流产。尽早应用解痉及宫缩抑制剂较为重要，是决定使妊娠是否继续的关键。从2012年2月我们开始使用间苯三酚联合中药及黄体酮治疗早期先兆流产，取得了满意的临床效果。
1 资料与方法
1.1 一般资料 选择2012年2月至2013年8月的住院病例，患者年龄22～36岁，平均年龄(27.62±5.41)岁，妊娠8～12周诊断为先兆流产的孕妇86例，15ng/ml0.05)。
1.2 早期先兆流产的诊断标准 妊娠12周前先出现少量阴道流血，暗红色或血性白带，无妊娠物排出，随后出现阵发性下腹痛或腰背痛。妇科检查宫颈口未开，胎膜未破，子宫大小与停经周数相符[1]。
1.3 治疗方法 实验组：间苯三酚120mg(南京恒生制药有限公司)加入5%葡萄糖500ml静脉点滴，滴速30滴/分，一日一次，症状及体征消失停用。口服中药，方用寿胎丸《医学衷中参参西录》加减：菟丝子12g，桑寄生15g，续断20g，党参10g，白术12g，杜仲10g，黄芪(生)10g，熟地10g，酒萸肉6g，地榆炭10g，一副水煎一日两次服用，连用至少4周。黄体酮20mg肌注，一日一次，每周检测一次血清孕酮水平，当孕酮>40ng/ml，改为口服黄体酮胶丸100mg，一日一次，一周后停用。对照组：用黄体酮及中药，用法同实验组。嘱患者卧床休息，禁止性生活，尽量减少阴道检查。
1.4 观察指标 ①有效：宫缩抑制，腹部不适缓解，阴道流血减少渐停止，胚胎或胎儿正常生长。②无效：妊娠组织排出，妊娠终止。③用药及住院时间。④药物不良反应。, http://www.100md.com(李洪菊 卢培玲 靳桂香)