摘要：目的观察蟾酥对蟾蜍坐骨神经电生理特性的影响。方法将剥制的蟾蜍坐骨神经干分为4组，分别在林格溶液和浓度为0.1 %，0.2 %，0.4 %的蟾酥溶液中浸泡，测定各组不同浸泡时间坐骨神经干动作电位的幅度、宽度、传导速度、引起动作电位的阈强度及不应期等电生理指标。结果经不同浓度蟾酥溶液处理后，引起神经干动作电位的阈强度和动作电位的宽度均增大，不应期延长，传导速度减慢。结论蟾酥可降低神经的兴奋性，减慢传导速度。

    关键词：蟾酥；蟾蜍；坐骨神经；动作电位；阈强度

    中图分类号：Q954.67文献标识码：A文章编号：1672-979X(2008)05-0017-04

    Influence of Toad Venom on Electrophysiological Character of Toad’s Sciatic Nerves

    ZHANG Wei-wei, LI Zhao-ping, AI Hong-bin*

    (College of Life Science, Shandong Normal University, Key Laboratory for Animal Anti-Stress Biology of Shandong Province, Jinan 250014, China)

    Abstract：Objective To study the influence of toad venom on the electrophysiological character of toad’s sciatic nerves. Methods The toad’s sciatic nerves were divided into four groups：Group I was immersed in normal Ringer’s solution ......