摘要：随着抗生素在临床上的广泛应用，许多细菌产生了耐药性，尤其表现为多药耐药性，影响了抗感染的疗效。其中由细菌排出泵介导的阻止药物在体内积累是产生抗性的重要手段之一。本文主要对近年研究的临床相关细菌及其排出泵、泵的调控机制和可能的生理功能做一综述。

    关键词：多药耐药；排出泵；致病菌

    中图分类号：R969文献标识码：A文章编号：1672-979X(2009)01-0065-04

    Study on Efflux Pump-mediated Multidrug Resistance of Clinical Pathogenic Bacteria

    WANG Qiu-yan1, SHI Lei2*

    (1. School of Bioscience and Bioengineering; 2. College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China)

    Abstract：With the wide use of antibiotics, many bacteria have acquired drug resistance, especially multidrug resistance, which affects the therapeutic effect of anti-infection. To prevent the accumulation of intracellular drug with efflux pumps is one of the means of producing drug resistance. This article reviews the clinically relevant bacteria and their pumps, the mechanisms of regulation and the putative natural roles of efflux pumps.

    Key words：multidrug resistance; efflux pump; pathogenic bacteria

    随着抗生素的发展及其在临床上的广泛应用，许多细菌产生了耐药性导致感染性疾病治疗失败。其中由细菌排出泵介导阻止药物在菌体内积累是产生耐药性的重要手段之一。抗生素敏感性、抗性细菌中都存在排出泵基因和蛋白质 ......