[摘要] 目的：探讨激素替代治疗(HRT)的安全性。方法：2002年1月~2007年1月用HRT治疗绝经期妇女106例，应用尼尔雌醇和安宫黄体酮。每半年进行妇科、乳腺的B超检查，每年进行血生化系列检查。结果：用药后高密度脂蛋白胆固醇(HDL-C)明显上升(P<0.05),低密度脂蛋白胆固醇(LDL-C)明显下降(P<0.05)，甘油三脂(TG)无明显变化。子宫出血例数在绝经初期为多，用药后子宫内膜厚度和乳腺增生程度无明显增加。结论：定期对接受HRT的妇女进行检查和评价，使HRT的应用更为安全有效。

    [关键词] 激素替代治疗；子宫内膜；血脂

    [中图分类号]R588[文献标识码]C [文章编号]1673-7210(2007)10(c)-151-02

    Five year’s security research in postmenopausal women by hormone replacement therapy

    WANG Xu-xia

    (Department of Gynaecology and Obstetrics,Taian Women and Children Care Hospital of Shandong,Taian 271000, China)

    [Abstract] Objective: Discussing the safety of HRT.Methods: A total of 106 cases was postmenopausal womentreated with HRT used nilestriol and medroxyprogesterone during 2002~2007.Every half year they carried on the gynecology department and the mammary gland B ultra inspection, carried on the blood biochemistry series of inspection every year ......