Survivin、bck-2蛋白在白血病中的表达及相关性探讨(1)
第1页 |
参见附件(758KB,3页)。
[摘要] 目的:探讨急性白血病骨髓细胞中Survivin、bcl-2蛋白的表达及相关性。方法:采用免疫组化S-P法检测70例白血病患者骨髓细胞Survivin、bcl-2蛋白表达情况。结果:病例组、ANLL、ALL、CML组Survivin、bcl -2蛋白阳性表达率明显高于对照组,差异有显著性(P<0.01);ANLL、CML组Survivin、bcl-2蛋白阳性表达率明显高于ALL组,差异有显著性(P<0.01);而ANLL与CML组之间差异无显著性(P>0.05);Spearman秩和相关分析显示,Survivin、bcl-2蛋白表达呈显著正相关(rs=0.32,P<0.01)。结论:Survivin、bcl-2均与白血病发生、发展密切相关,且两者有一定的协同效应。
[关键词] 白血病;Survivin;bcl-2;凋亡
[中图分类号] R733.7[文献标识码]A [文章编号]1673-7210(2008)03(b)-019-03
The significance and correlation of Survivin and bcl-2 proteins expression in leukemia
WANG Ye
(Department of Hematologist, Shenyang Red Cross Hospital, Shenyang 110013, China)
[Abstract] Objective:To examine the expression of Survivin and bcl-2 proteins in bone marrow cells of leukemia, and to detect correlation of them.Methods:S-P immunohistochemistry detected the expression of Survivin and bcl-2 in bone marrow cell of 70 cases whith leukemia. Results:The positive expression rates of Survivin and bcl-2 in patient group ,ANLL,ALL and CML were higher than in control group, with significant difference(P0.05). The related analysis of Spearman showed the Survivin and bcl-2 were closely positive related(rs=0.32,P
您现在查看是摘要介绍页,详见PDF附件(758KB,3页)。