气相色谱法测定维生素K1中残留溶剂的含量
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[摘要] 目的：测定维生素K1中甲醇、正己烷、乙酸乙酯和甲苯的含量。方法：采用毛细管气相色谱法，OV-101色谱柱，程序升温，载气为氮气，检测器为FID，外标法计算含量。结果：在选定的色谱条件下，测得各有机溶剂的含量与峰面积线性关系良好(r>0.99)；甲醇、正己烷、乙酸乙酯和甲苯的平均加样回收率分别为100.60%、98.65%、101.42%、101.62%。三批样品中4种有机溶剂残留量均符合规定。结论：经方法学验证，该方法灵敏、准确，适用于本品有机溶剂残留的测定。
[关键词] 维生素K1；有机溶剂残留；气相色谱法
[中图分类号]R927 [文献标识码]A [文章编号]1673-7210(2008)07(b)-035-02
Determination of residual organic solvents in Vitamin K1 by gas chromatography
MAO Ying1, BI Zhong-zhou1, DENG Zhi-jian2
(1.Henan Sunny Pharmaceutical Co. LTD., Kaifeng 475000, China;2.The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China)
[Abstract] Objective: To determine the contents of the residual methanol, n-hexane, ethyl acetate and toluene in Vitamin K1. Methods:The capillary gas chromatography method was established with FID detector. The capillary column was OV-101 with programmed temperature rising ......
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