喷昔洛韦眼用凝胶的制备及质量控制
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[摘要] 目的：制备喷昔洛韦眼用凝胶并建立其质量控制方法。方法：以PVA-124为主要基质制成眼用凝胶；采用高效液相色谱法测定其主药喷昔洛韦含量，测定波长为252 nm。结果：喷昔洛韦检测浓度在5.00~100.00 μg/ml范围内线性关系良好(r=0.999 7)，平均回收率为98.71%(RSD=0.75%)。结论：本方法简便﹑准确﹑重现性好，可用于喷昔洛韦眼用凝胶的质量控制。
[关键词] 喷昔洛韦；眼用凝胶；制备；质量控制
[中图分类号]R944 [文献标识码]A [文章编号]1673-7210(2008)07(c)-034-02
Preparation and quality control of Penciclovir Ophthalmic Gel
ZHU Ji-feng1, LI Jin-wei2,MENG Xian-li2
(1.The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;2. Henan Provincial People′s Hospital, Zhengzhou 450003,China)
[Abstract] Objective: To prepare and establish quality control for Penciclovir Ophthalmic Gel.Methods:Penciclovir Ophthalmic Gel was prepared with PVA-124.The content of penciclovir was determined by HPLC at the wavelength of 252 nm.Results: There was a good linear correlation within the range of 5.00~100.00 μg/ml(r=0.999 7)of penciclovir concentration; the average recovery was 98 ......
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