小儿氨酚黄那敏片中对乙酰氨基酚含量的HPLC测定
 |
| 第1页 |
参见附件(189KB，2页)。
[摘要] 目的：建立高效液相色谱(HPLC)法测定小儿氨酚黄那敏片中对乙酰氨基酚含量。方法：采用安捷伦 Eclipse XDB-C18 色谱柱(150 mm×4.6 mm,5 μm)，甲醇-水(80∶20)为流动相，流速为0.8 ml/min，柱温为30℃，检测波长为249 nm。结果: 对乙酰氨基酚在0.200 5～2.004 8 μg 范围内呈良好线性关系，r=0.999 9，平均回收率为99.82%，RSD为0.23% (n=6)。结论：该法稳定、简便，可用于小儿氨酚黄那敏片的质量控制。
[关键词] 小儿氨酚黄那敏片；高效液相色谱法；对乙酰氨基酚
[中图分类号] R927[文献标识码]A [文章编号]1673-7210(2008)08(c)-053-02
Determination of Paracetamol in Xiao'er Anfen Huang Namin Tablets by HPLC
GUO Xu-feng,WU Si-qiang,LIANG Jin-hui
(Zhaoqing City Institute of Drug Control, Zhaoqing526040,China)
[Abstract] Objective：To establish an HPLC method for the determination of Paracetamol in Xiao'er Anfen Huang Namin Tablets. Methods： Agilent Eclipse XDB-C18(150 mm×4.6 mm, 5μm) column was used. The mobile phase consisted of methanol and water(80∶20),the flow rate was 0.8 ml/min,column temperature was 30℃ and wavelength of detecting at 249 nm. Results： The linear range of paracetamol was within 0.200 5～2.004 8 μg, (r=0 ......
您现在查看是摘要介绍页，详见PDF附件(189KB，2页)。