维生素C催化合成阿司匹林的条件研究
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[摘要] 目的:以维生素C为催化剂、水杨酸为原料、醋酐为酰化剂,合成阿司匹林。方法:采用乙酰化法合成。结果:初步确定了合成条件,温度为80℃,反应时间为40 min,维生素C用量为0.2 g,收率为56.8%。结论:本方法可行,合成条件需进一步完善。
[关键词] 维生素C;合成条件;阿司匹林;研究
[中图分类号]R914.5 [文献标识码] A[文章编号] 1673-7210(2009)07(c)-058-02
Condition investigation on the synthesis of Aspirin by vitamin C catalyst
NIE Xin, WENG Mingtu, CUI Jianqing, XU Zhenqun, HOU Weile
(School of Medicine, Foshan University, Foshan 528000, China)
[Abstract] Objective: To synthesize Aspirin by using vitamin C as the catalyst, salicylic acid as the raw material and acetic anhydride as the acylating agent. Methods: The method of acetylation was used. Results: The synthesis conditions was determined, the temperature was 80℃, the reaction time was 40 min, the quantity of vitamin C was 0.2 g, the yield was 56.8%. Conclusion: The method is feasible, and the synthesis condition needs to be improved ......
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