拉米夫定对肺结核并HBV感染患者的作用及意义(1)
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[摘要] 目的:观察拉米夫定对肺结核并乙型肝炎病毒(HBV)感染患者的作用。方法:标准化疗的41例血清HBV-DNA阳性的肺结核并HBV感染患者,随机分成拉米夫定抗病毒治疗组21例,对照组20例。治疗组用拉米夫定0.1 g/d,对照组未用拉米夫定。两组患者均随访至4.3年。结果:化疗中,肺结核并血清HBV-DNA阳性抗病毒组,肺结核并血清HBV-DNA阳性未抗病毒组,肺结核并HBV-DNA阴性、其他HBV-M阳性组,单纯肺结核组,肝功能受损率分别为28.57%,95.00%,9.68%及5.07%。肺结核并血清HBV-DNA阳性,未抗病毒组死亡与肝病直接相关。结论:肺结核并HBV感染,且HBV复制,化疗中应用拉米夫定有重要意义,是治疗肺结核并HBV感染的一种新型有效的方法。拉米夫定抗HBV治疗,对改善存在HBV复制的肺结核患者预后有重要作用。
[关健词] 结核;肺;乙型肝炎病毒;脱氧核糖核酸;拉米夫定
[中图分类号] R521[文献标识码]A [文章编号]1673-7210(2009)07(c)-079-03
The effect and significance of Lamivudine in treating pulmonary tuberculous complicated with HBV infections
XU Feng1, WANG Zhengchun1, WANG Yanhua4, PENG Yi2, WANGFeng1, ZHENG Jun3, Luo Juzhen1, XIAO Musheng4, XU Qiangsheng4, XU Yuying5
(1.Shenzhen Henggang People's Hospital, Shenzhen 518115, China; 2. Shenzhen Chronic Disease Hospital,Shenzhen518020,China; 3.Bao'an Chronic Disease Hospital of Shenzhen, Shenzhen 518100, China; 4.Infectious Disease of Huangshi, Huangshi 435000, China; 5.Medical Institute, Huangshi University of Technology, HuangShi 435000, China)
[Abstract] Objective: To observe the effects of Lamivudine in treating pulmonary tuberculous complicated with Hepatitis B virus (HBV) infections. Methods:41 patients with pulmonary tuberculosis complicated with HBV infections were divided into two groups randomly, 21 patients in treating group and 20 patients in control group. On the basis of antituberculous chemotherapy, the treating group were treated by Lamivudine, and the control group were not treated by Lamivudine. The patients had been followed up for 4.3 years. Results: In the course of antituberculous chemotherapy ,the abnormal Liver function rate turned to be 95.00%, in the control group but only 28.57%, and only 9.68% and 5.07% in the negatives,HBV-DNA group and pulmonary tuberculosis group respectively ......
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