Synthesis of unsaturated fatty acid derivatives of 4-aminosalicylic ac(3)

http://www.100md.com 2010年3月25日 Jiang Aiwen,Zhao Zhengbao

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     Benzylchloroformate(carbobenzyloxy chloride) (0.054 mol) was added dropwise gradually to a suspension of compound 3 (0.04 mol) in solution of methylene chloride (80 ml) and pyridine (20 ml). The reaction mixture was stirred mechanically 4 hours under 0℃, then the solvent was removed by reducing evaporator. The resulting solid was recrystyllized with methanol and ethyl acetate to give compound 4.

    4: White solid, 87% yield, mp: 141-143℃.

    1.5 Preparation of 4- [N-(Benzyloxycarbonyl) amino] 2-acetoxysalicylic Acid methyl ester 5

    To the compound 4 (0 ......

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