七氟醚对肺癌患者围术期TNF-α的影响(1)
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[摘要] 目的:观察七氟醚对肺癌患者围术期血清中肿瘤坏死因子α(TNF-α)的影响。方法:选择30例Ⅰ～Ⅱ期肺癌择期行左侧开胸肺叶切除手术患者,ASAⅠ～Ⅱ级,随机分为芬太尼组(C组)和七氟醚组(S组)。分别于麻醉诱导前1 min(T1),单肺通气40 min(T2)、90 min(T3)和120 min(T4)时取外周静脉血样测TNF-α浓度。结果:单肺通气后两组TNF-α水平均较单肺通气前显著升高(P<0.05)。单肺通气(OLV)后T3、T4时刻TNF-α水平 C组显著高于S组(P<0.05)。结论:七氟醚可降低肺癌患者血清TNF-α的浓度,减轻围术期的全身炎症反应。
[关键词] 七氟醚;肺癌;肿瘤坏死因子;全身炎症反应
[中图分类号] R614.2[文献标识码]A [文章编号]1673-7210(2010)04(b)-045-02
Effect of sevoflurane on the serum concentration of TNF-α during the periperative period in lung carcinoma patients
LIU Jun1, DONG Youjing2
(1.Weikang Hospital of Shenyang City, Shenyang 110020, China; 2.Department of Anesthesia, Shengjing Hospital of China Medical University, Shenyang 110004, China)
[Abstract] Objective: To study the effect of sevoflurane on the alternation of serum concentration of TNF-α during the periperative period in patients undergoing pulmonary lobectomy of left-thoracis surgery ......
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