大剂量阿托伐他汀在冠心病患者介入术后的疗效观察(1)
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[摘要] 目的:观察大剂量阿托伐他汀在冠心病患者介入术后的疗效及安全性。方法:选择74例成功冠脉介入治疗术后患者随机分为两组,在常规治疗基础上治疗组采用阿托伐他汀80 mg/d、对照组采用阿托伐他汀20 mg/d,观察两组患者用药后3个月的心脏缺血事件、血脂和高敏C反应蛋白水平(hs-CRP)及不良反应。结果:心脏缺血事件的发生率治疗组低于对照组,有显著性差异(P<0.05)。血脂和C反应蛋白水平降低治疗组好于对照组,有显著性差异(P<0.05)。服药1个月后两组(治疗组6例、对照组4例)均有谷丙转氨酶轻度升高,两组间无显著性差异(P>0.05)。结论:大剂量阿托伐他汀用于冠心病患者介入术后疗效显著,无严重不良反应。
[关键词] 阿托伐他汀;冠心病介入术;不良反应
[中图分类号] R541[文献标识码]C [文章编号]1673-7210(2010)06(a)-079-02
Clinical observation of high-dose Atorvastatin in patients with coronary heart disease after intervention
JIANG Shaojun, ZHAO Xiaohong
(Department of Neurology, Langzhong People's Hospital of Sichuan, Langzhong 637000, China)
[Abstract] Objective: To observe the efficacy and safety of high-dose Atorvastatin in patients with coronary heart disease after intervention. Methods: 74 patients after successful coronary intervention were randomly divided into two groups, based on the conventional therapy the treatment group with Atorvastatin 80 mg/d and the control group with Atorvastatin 20 mg/d, the ischemic event, blood lipids and high sensitivity C reactive protein (hs-CRP), and adverse reactions of two groups were observed after 3 months. Results: The incidence of cardiac ischemic events in treatment group was lower than the control group, there was significant difference (P<0.05).Lipids and C-reactive protein levels decreased in treatment group was better than the control group, there was significant difference (P<0.05). Medication groups after 1 month [treatment group (6 cases), control group (4 cases)] had slightly elevated alanine aminotransferase, there was no significant difference between the two groups (P>0.05). Conclusion: High-dose Atorvastatin therapy in patients after coronary intervention has notable curative effect and no serious side effects.
[Key words] Atorvastatin; Coronary intervention; Adverse reactions
冠心病是中老年人的常见病及多发病,经皮冠状动脉介入治疗(PCI)是治疗冠心病的手段之一,其术后阿托伐他汀的应用也非常重要,它可以降低PCI术后心血管事件的发生率[1]。本研究通过对冠心病介入术后的患者应用阿托伐他汀20 mg/d和80 mg/d进行了观察,现报道如下:
1 资料与方法
1.1 一般资料
2007年8月～2009年3月接受冠脉介入治疗成功的患者共74例,男46例,女28例;年龄32～81岁,平均(60.2±8.7)岁;其中,不稳定型心绞痛38例,ST段抬高型心肌梗死22例,非ST段抬高型心肌梗死14例 ......
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