PCNA和CD44v6在鼻咽癌组织中的表达及其相互关系(1)
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[摘要] 目的：研究PCNA和 CD44v6在鼻咽癌的表达及其相互关系。方法：应用免疫组化S-P法检测 23例慢性鼻咽炎、62例鼻咽癌组织(38例伴有淋巴结转移)中PCNA和 CD44v6的表达。结果：62例鼻咽癌组织PCNA和CD44v6阳性表达率分别为69.3%、77.4%，与23例慢性鼻咽炎PCNA、CD44v6阳性率比较，差异有统计学意义(P<0.05)。鼻咽癌转移组和非转移组PCNA的阳性率分别为68.4%、70.8%，差异无统计学意义(P>0.05)；转移组CD44v6阳性率要高于非转移组，阳性率分别为89.4%、58.3%，差异有统计学意义(P<0.05)。PCNA和CD44v6共同阳性表达有39例，共同阴性表达10例，两者表达呈正相关(r=0.436， P<0.01)。结论：PCNA和 CD44v6在鼻咽癌组织中存在高表达，在鼻咽癌的发生、发展中起着重要作用。
[关键词] 鼻咽癌；PCNA；CD44v6；转移
[中图分类号] R739.6[文献标识码]A [文章编号]1673-7210(2010)10(a)-016-03
The expression of PCNA and CD44V6 in nasopharyngeal carcinoma and their relationship
CAI Liangzhen, ZHI Meifen, HE Wenyan
(Department of Oncology, the Affiliated Hospital Guang Dong Medical College, Zhanjiang 524000, China)
[Abstract] Objective: To investigate the expression of PCNA and CD44v6 in nasopharyngeal carcinoma (NPC) and their relationship. Methods: the expression of PCNA and CD44v6 were detected in 23 cases chronic nasopharyngitis and 62 NPCs (38 cases with lymph node metastases) by S-P immunohistochemical method. Results: The positive expression rates of PCNA and CD44V6 were 69.3% and 77.4% in 65 NPCs，showing statistical difference from those of 23 cases chronic nasopharyngitis (P<0.05). The positive expression rates of PCNA in metastasis group and non-metastasis group were 68.4%，70.8%, there was no statistical significance(P>0.05); The positive expression rates of CD44v6 in metastasis group and non-metastasis group were 89.4%,58.3%,there was statistical significance (P<0.05). PCNA and CD44V6 were expressed positively in 39 cases，while being expressed negatively in 10 cases, showing positive correlation between them(r=0.436, P<0.01). Conclusion: PCNA and CD44v6 is high expression in NPCs, playing important roles in the occurrence and development of NPC.
[Key words] Nasopharyngeal carcinoma; PCNA; CD44v6; Metastasis
研究鼻咽癌浸润与转移的分子机制，确定鼻咽癌转移的分子标志物，对鼻咽癌的诊断与治疗有着深刻的意义[1]，增殖细胞核抗原(PCNA)和 CD44v6在鼻咽癌组织中存在高表达，在鼻咽癌的发生、发展中起着重要作用。
PCNA是一种36kD的酸性核蛋白，为DNA 聚合酶δ的辅因子，主要在G1早期和S后期诱导DNA的合成 ......
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