围术期静注恩再适用于腰椎术后自控镇痛(1)
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[摘要] 目的：评价围术期静注恩再适对腰椎手术后患者自控静脉镇痛的效果。方法：选择全麻下行腰椎手术的患者100例，术后采用芬太尼行患者自控静脉镇痛(PCIA)，并随机分为两组，每组50例：恩再适组(A组)，术前晚、麻醉前、术毕各经静脉注射恩再适7.2 U，芬太尼0.5 mg+生理盐水共100 ml镇痛；芬太尼组(F组)，芬太尼0.5 mg+生理盐水共100 ml镇痛。术后24 h内采用视觉模拟评分(VAS)、PCA按压次数来观察各组镇痛效应及恶心、呕吐、嗜睡等不良反应的发生率。结果：F组术后2 h时的VAS评分显著高于A(P<0.05)，而4 h后的VAS两组比较，无显著性差异(P>0.05)。24 h内的PCA按压次数F组显著多于A组(P<0.05)。A、F组中恶心、呕吐、皮肤瘙痒及嗜睡等不良反应的发生率比较无显著性差异(P>0.05)。结论：围术期静注恩再适复合小剂量芬太尼用于腰椎手术后静脉镇痛可取得满意的镇痛效果。
[关键词] 恩再适；芬太尼；镇痛；静脉；腰椎切开术
[中图分类号] R614 [文献标识码] A[文章编号] 1673-7210(2010)10(a)-072-02
Clinical effect of perioperative injection of Analgecine on patient-controlled intravenous analgesia in lumbotomy patients
WU Shimin1, ZHANG Xianwei2, LU Bo1, LI Yueqiong1, DAI Ping1
(1.Department of Anesthesiology, Fuyong People's Hospital, Shenzhen 518103, China; 2.Department of Anesthesiology,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China)
[Abstract] Objective: To evaluate the effect of perioperative intravenous injection of Analgecine on the analgesia efficacy and complications of patient-controlled intravenous analgesia(PCA) in postoperative lumbotomy patients. Methods: 100 patients undergoing lumbotomy in general anesthesia were randomly divided into two groups with 50 cases each: Analgecine group (A) and Fentanyl group (F). Both groups were received 0.5 mg Fentanyl diluted to Physiological Saline 100 ml and infused by pumps. Besides, the patients in group A were injected with Analgecine 7.2 U at the night before the operation, preoperation and postoperation respectively. The visual analog scale(VAS), times of PCA and incidence of adverse reactions were recorded 24 hours after operation. Results: The VAS of group F at 2 h after operation was significantly higher than that of group A (P<0.05), which became similar after 4 h (P>0.05). The demanding times of compressions of PCA in group F were also significantly higher than that of group A (P<0 ......
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